proteomics – TechConnect Briefs

In vivo nanotoxicology: Toxicoproteomics

Sabella S., Kote S., Pompa P.P., Italian Institute of Technology, IT

Proteomics applied to nanotechnology is now emerging as an attractive tool to address the still unanswered questions dealing with nano-biointeractions and NPs-induced toxicity in living systems. The unique advantage provided by “omic” techniques (such as, [...]

Hollow-fiber flow field-flow fractionation: a novel pre-MS method for proteomics

Rambaldi D., Zattoni A., Reschiglian P., Johann C., University of Bologna, IT

It is well acknowledged that both number and dynamic range of the proteins present in biological systems lead to the need of a “simplified” and more efficient way to proteome analysis. The availability of so-called [...]

Modulation of g-Irradiation Induced ROS Responses by Engineered Fullerenes in Human Epidermal Keratinocytes

Gao J., Wang H.-L., Shreve A.P., Iyer R., Los Alamos National Laboratory, US

High-dose ionizing irradiations can cause acute tissue and organ damage, especially severe cutaneous lesions. These cutaneous injuries often result in further complications and incur high mortality. Therefore, it is critical to develop effective therapeutic approaches [...]

Genomics and Proteomics: Information-Theoretic Analysis in Frequency Domain

Lyshevski S.E., Krueger F., Rochester Institute of Technology, US

We perform the frequency-domain analysis to examine large-scale genomic and proteomics data. This ensures qualitative and quantitative coherency.

An OMICs Approach for Assessing the Safety of Single-Walled Carbon Nanotubes in Human Skin and Lung Cells

Cunningham M.J., Shah M., Lema C., Magnuson S., Falduto M., Balzano L., Resasco D., Houston Advanced Research Center, US

High-throughput OMICs biotechnologies combined with a systems biology approach were used to screen for the toxicity of nanomaterials. Profiling of the macromolecular interactions within human cells was done with mRNA and miRNA expression microarrays (genomics) [...]

Ion Sources for Biomolecules with Controlled Superposition of Electric and Pneumatic Fields

Hieke A., Ciphergen Biosystems, Inc., US

As previously reported the design of advanced ion sources for collisionaly cooled biomolecules required the development of an advanced multi-physics simulation system GEMIOS (Gas and Electromagnetic Ion Optical Simulator). Recent research based on such GEMIOS [...]

Dry Microarrays: A Generalized Data Source for Genome and Proteome Analysis

Sampath G., The College of New Jersey, US

Microarray analysis methods can be applied to characteristic data obtained from biological sequences in matrix form (which could include data from experiments or bioassays as well). The rows correspond to a genome region (intron or [...]