protein delivery – TechConnect Briefs

Lipid nanoparticles for enhancing immune responses to protein antigens

Courant T., Reynaud H.L., Hoang A., Villiers C., Mittler F., Texier I., Marche P.N., Navarro F.P., CEA/LETI/MINATEC, FR

In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]

New carrier for protein and drug delivery based on injectable Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) pH/temperature hydrogel

Lee D.S., Huynh D.P., Sungkyunkwan University, KR

Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) - a novel pH/temperature sensitive and biodegradable hydrogel copolymer used for drug and protein delivery was synthesized. Bovine insulin (BI) and human growth hormone (HGH) loaded well to the copolymer [...]

Amphiphilic Self-assembled Nanoparticles Composed of Chitosan and Ursolic Acid for Protein Delivery on the Skin

Lee S.B., Cho K., Shim J.K., Korea Institute of Industrial Technology, KR

Several promising studies have been reported for the protein delivery such as cytokines using nano-sized particles, which have detrimental effect on the loading the protein without localization and releasing it without deactivation. To design the [...]

Construction of Enzymosomes: Optimization of Coupling Parameters

Vale C.A., Corvo M.L., Martins L.C.D., Martins M.B.F., Marques C.R., Storm G., Cruz M.E.M., Martins L.C.D., Martins M.B.F., Laboratorio Nacional de Engenharia, Tecnologia e Inovacao, IP, PT

Different strategies can be used to improve carrier mediated delivery of therapeutic proteins. The incorporation of therapeutic enzymes into polymeric carriers [1], into aqueous space of lipid vesicles [2] or lipid-detergent vesicles [3, 4] or [...]