Characterization of Crosslinked Polymer Nanoparticles by Size-Exclusion Chromatography Coupled to Differential Viscometery

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Conventional size-exclusion chromatography (SEC) and size-exclusion chromatography coupled to differential viscometry (SEC/DV) methodologies have been developed and applied to the dilute suspension characterization of solvent-swollen crosslinked unimolecular polymeric nanoparticles (PNPs) in the 5 ~ 50 [...]

Nonclinical evaluation of heparin binding copolymer – HBC1 for restoring of blood coagulation after heparin treatment

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The incredible progress and wide use of various medical devices during intravascular or cardiac interventions increased the need for administration of anticoagulants, such as heparins. Protamine sulfate – a protein isolated from salmons is the [...]