PEGylation – TechConnect Briefs

Modeling of polypeptide- and polymer-conjugated nanoparticles for drug delivery application

Lee H.K., Dankook University, KR

Nanoparticles such as liposomes, dendrimers, and carbon nanotubes have many potential biomedical applications as antitumor therapeutics and drug delivery. These applications require the interaction of those with cell membranes, thus interactions of nanoparticles, polymers, and [...]

Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates

Yang T., Bouchard B., Cook A., Hu J., Hao J., Bai S., Husson University, US

Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for [...]

Targeted Cancer Therapy by Immunoconjugated Gold-Gold Sulfide Nanoparticles Using Protein-G as a Cofactor

Sun X.H., Zhang G.D., Patel D., Gobin A.M., University of Louisville, US

Gold-gold sulfide nanoparticle (GGS-NP) with controllable near infrared (nIR) absorption was synthesized from a simple reaction of chloroauric acid and sodium thiosulfate. Through PEGylated recombinant Protein-G (ProG), ProG-conjugated GGS-NPs for antibody capture by Fc domain [...]

Photothermal Characteristics study of PEGylated Gold Nanorods

Shih T-Y, Lin J-T., Tien C.C., Tseng P-L, Chen Y-H, Industrial Technology Research Institute, TW

Gold nanorods have a growing role in a diversity of medical applications especially in the area of hyperthermal therapy of tumor. Since localized temperature rising by laser irritation gold nanorods at near-IR frequency can induce [...]

Cytotoxicity of bare and PEGylated silica nanoparticles as potential gene-delivery vectors

Yagüe C., Saldaña L., Martin F., Arruebo M., Vilaboa N., Santamaria J., Universidad fe Zaragoza, ES

Silica and other inorganic carriers are one of the major groups used to transport drugs and bioactive molecules into cells. The others are viral carriers, organic cationic compounds and recombinant proteins. The use of mesoporous [...]