molecular recognition – TechConnect Briefs

Molecular imprinted nanoPolymer nanomaterials: application in biomolecule recognition

Sharma A., Sharma R., Sharma A., Sharma R., Innovations and Solutions Inc., US

Molecular imprinting has proved to be an effective technique for generating specific recognition sites in synthetic nanopolymers. These sites are tailor-made in situ by copolymerization of functional monomers and cross-linked around the template molecules. The [...]

NANOCYTES-Technology – Biomimetic nanoparticles for molecular recognition by molecular imprinting

Schreiber T., Niedergall K., Wojciukiewicz D., Gose T., Gruber-Traub C., Weber A., Hirth T., Tovar G.E.M., University of Stuttgart & Fraunhofer Gesellschaft, DE

Communication of living systems is done by molecular recognition. This central principle of the living world is performed at the contact sites of different objects such as single macromolecules or highly complex supramolecular assemblies as [...]

Modified AFM Probes for Nanoscale Biomolecular Recognition Studies

Johnson W.T., Agilent Technologies, US

Biomolecular interactions, which are responsible for many physiologically important processes, can be studied by molecular recognition force microscopy (MRFM). In MRFM, nanoNewton scale single molecule interactions are observed and quantified one by one as an [...]

Attaching Biological Molecules to AFM Probes for Nanoscale Molecular Recognition Studies

Travis Johnson W., Agilent Technologies, US

Atomic Force Microscopy (AFM) is an important tool for nanoscale molecular recognition studies. A strong suit of AFM is its ability to measure hardness/elasticity, nonspecific adhesion, or ligand-receptor interactions at the picoNewton scale. Molecular interactions [...]

Biofunctional core-shell nanoparticle deposition for biochip creation by printing processes

Borchers K., Weber A., Genov S., Wirth I., Grzesiak A., Tovar G.E.M., Fraunhofer Institute for Interfacial Engineering and Biotechnology, DE

Nanoparticles display a very large surface-area. Therefore, coatings of functional nanoparticles adsorbed to a solid substrate yield an enlarged interface per footprint-area which is highly appreciated for probe-immobilization in bio-chip technology [1,2]. Silica nanospheres, equipped [...]

Identifying Nanoscale Molecular Binding Events With SPM/AFM

Johnson W.T., Agilent Technologies, US

PicoTRECTM is a chemical/biological detection accessory for the Agilent SPM/AFM (scanning probe microscopy/atomic force microscopy) that combines molecular scale imaging with nanoscale, molecular recognition mapping. It is being used to map interactions between antibodies/antigens and [...]

Silver Particle and Silver Thiolate-Based Molecular Sensing/Recognition Units Operating via Surface-Enhanced Raman Scattering

Kim K., Kim N.H., Park H.K., Kim K., Kim N.H., Lee H.S., Lee Y.M., Lee H.S., Lee Y.M., Seoul National University, KR

Noble metallic nanostructures exhibit a phenomenon known as surface-enhanced Raman scattering (SERS) in which the scattering cross sections are dramatically enhanced for molecules adsorbed thereon. We demonstrate that commercially available Ag(μAg) powders can be used [...]

Odor sensor using quartz crystal microbalance coated with molecular recognition membrane

Nanto H., Takei Y., Imamura T., Ishigure D., Kanazawa Institute of Technology, JP

Quartz crystal microbalance (QCM) gas sensor coated with thin molecular recognition membrane using acrylic acid, methacrylic acid or stylene are prepared using plasma-polymerized chemical vapor deposition (CVD)method. The sensor coated with acrylic acid thin film [...]

Investigation of Interaction Between Subparts in Human Hemoglobin Using Concept of Conjugated Ion-Hydrogen Bonds Systems and Its Application to Biosensors Development Problem

Luchinin V.V., Demchenko E.L., Karasev V.A., St. Petersburg State Electrotechnical University, RU

The novel concept of conjugated ion-hydrogen bonds system as the basic charge-,energy- and siganl-transferring structure on the proteins, proposed by authors in previous publications, is demonstrated with the help of a new compueter program, developed [...]