microsphere – TechConnect Briefs

Nitric oxide releasing PLGA microspheres for biomedical applications

Lautner G., Schwendeman S.P., Meyerhoff M.E., University of Michigan, US

In the current work, we encapsulated an S-nitroso species in biodegradable poly(lactic-co-glycolic acid (PLGA) microspheres (with diameter of 20-125 µm) that release nitric oxide (NO) for weeks in a continuous and controlled manner. The rate [...]

Study on the Composite with Sequential and Sustained Release of Multiple Growth Factors for Bone Repair

Liao Y., Liu T.Y., Institute of Biomedical Engineering, National Yang-Ming University, TW

In this study, a PLGA/PVA microsphere and a chitosan-based hydrogel loading FITC were prepared to be a composite. The encapsulation of FITC in PLGA/PVA microspheres and the bonding of crosslink in chitosan-based hydrogel were confirmed. [...]

Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems

Pant K., Romanowicz B.F., Sundaram S., CFD Research Corporation, US

Microsphere and cell-based assays are emerging as the platform of choice for rapid quantitation of biomolecular interactions in bioagent detection, clinical diagnosis, drug therapy, etc. [1,2] Traditional assay designs have been driven by expensive trial-and-error [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed |omputational models for simulating sample detection using flowing beads. The model fully integrates [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed computational models for simulating sample detection using flowing beads. The model fully integrates [...]