microfluidics – Page 4 – TechConnect Briefs

All-In-Polymer Injection Molded Device for Single Cell Capture Using Multilevel Silicon Master Fabrication

Tanzi S., Larsen S.T., Matteucci M., Taboryski R., Technical University of Denmark, DTU Nanotech, DK

This work demonstrates a novel all-in-polymer device for single cell capture applicable for biological recordings. The chip is injection molded and comprises a “cornered” (non planar) aperture. Zanetti et al. have reported that mammalian cells [...]

Atomistic Simulations of Biomolecules at the Water‐Amorphous Silica Interface: Application to Peptides and DNA Oligomers

Shi B., Shin Y.K., Shin Y.K., Hassanali A., Singer S.J., Ohio State University, US

Realistic modeling of biomolecules near amorphous silica (“glass”), a material commonly used for biomedical device fabrication, is required for device design and evaluation. Our potential model, based on ab initio quantum chemical calculations, is designed [...]

Microfluidic manipulation of Caenorhabditis elegans using acoustic radiation forces

Yu G., Chen X., Xu J., Washington State University, US

The ability to precisely trap, transport and manipulate micrometer-sized objects is very important in microfluidic applications. Caenorhabditis elegans (C. elegans) is one of the most commonly used animals in biological and medical research due to [...]

Conductive Polymer Microelectrodes for on-chip measurement of transmitter release from living cells

Tylsgaard Larsen S., Matteucci M., Taboryski R., Technical University of Denmark, DK

In this work we present an all-polymer chip for measuring exocytotic release from neuronal cells using electrochemical sensing at a conductive polymer microelectrode. This chip combines several novel aspects, such as the use of conductive [...]

Fabrication and Characterization of HAR Microfluidic Device to Concentrate Microalgae

Singh V., Nguyen Q., Goettert J., Yemane D., Bargiel J., Lane C., Stephenson F., Louisiana State University, US

Algae are a promising candidate for large-scale production of biofuels, an important source of renewable energy [1]. A significant portion (20-40%) of the cost in the traditional processing comes from concentrating (dewatering) the algae from [...]

Colloido-Polymersomes: Capsules consisting of a composite layer of particles and polymer

Shum H.C., University of Hong Kong, HK

We present an approach to fabricate capsules consisting of a composite layer of particles and block copolymers . The capsules are fabricated by the directed assembly of block copolymers at the interfaces of a double [...]

Nano-plamsonics Sensing and Integration with Microfluidics for a Lab-on-chip Biosensor

Wei J.J., Rexius M., Kofke M., Wang Y., Singhal S., Waldeck D.H., CFD Research Corporation, US

Ordered arrays of nanostructures in metal films have been studied for practical miniaturization of SPR sensing and microfluidic integration. We report a nanostructure array that is designed to permit significantly enhanced Extraordinary Optical Transmission (EOT) [...]

Development of a capillary-driven, microfluidic, nucleic acid biosensor

He F., Jin S., Dai M., Nugen S.R., University of Massachusetts, US

An ideal point-of-care device would incorporate the simplicity and reliability of a lateral flow assay with a microfluidic device. Our system consists of self-priming microfluidics with sealed conjugate pads of reagent delivery and an absorbent [...]

CFD-Assisted Design and Optimization of a Pharmacokinetic Microfluidic System

Moeini Sedeh M., Khodadadi J.M., Hong J.W., Cramer K.A., Hamon M., Auburn University, US

In this research, a microfluidic system was designed and optimized to carry out in vitro pharmacokinetic studies of drug candidates in the liver. Computational fluid dynamics (CFD) was called on to assist in the system [...]

Microchannel for IOP Relief and Glaucoma Treatment

Barth D., Heureaux J., Pilapil B., Ponce de Leon P., Zhao K., Stevens Institute of Technology, US

An implantable biomedical device intended for glaucoma treatment was designed, modeled, fabricated, and tested. Glaucoma is a degenerative eye disease that is normally characterized by high Intraocular Pressure (IOP) and causes progressive vision loss. According [...]