micelles – TechConnect Briefs

Hybrid Programmable Peptide Crosslinkers as Enzyme-Regulated Drug Delivery Vehicles

Rouge J.L., University of Connecticut, US

Biology has evolved the quintessential nucleic acid delivery vehicle, the virus, using proteins built from self-assembled peptide subunits. These viral protein coats are then degraded by specific enzymes, depending on their location, releasing their contents [...]

Gold Nanoshells With Micellar Core for The Delivery of Hydrophobic Chemotherapeutic and Cancer Photothermal Therapy

Lee S-Y, Shieh M.J., National Taiwan University, TW

Gold nanoshells have attracted great research interest because of its potential application in cancer photothermal therapy. In the present study, we established a multifunctional gold nanoshell that directly utilizing positively charged PDMA-b-PCL micelles as a [...]

Micellar solutions as environmentally-friendly agents for cleaning artworks

Rathousky J., Remzova M., Zouzelka R., J. Heyrovsky Institute of Physical Chemistry, AS CR, CZ

Micellar solutions and microemulsions are efficient agents for cleaning artworks, especially for the selective removal of aged polymeric coatings from the surface of wall paintings. We have aimed at the development of a generalized method [...]

Epoxy Toughening with Nano-Sized Amphiphilic Block Copolymer Micelles

Liu D., Sue H-J, Thompson Z.J., Bates F.S., Hillmyer M.A., Exponent, Inc., US

A model diglycidyl ether of bisphenol A (DGEBA) epoxy resin was modified with a poly(ethylene-alt-propylene)-b-poly(ethylene oxide) (PEP-PEO) block copolymer to improve fracture toughness. Two distinct nanoscaled morphologies were achieved in the cured systems: spherical micelles [...]

Multi-functional micelles for the combination of chemotherapy and radiotherapy in hepatocellular carcinoma

Shih Y-H, Peng C.L., Luo T-Y, Shieh M.J., National Taiwan University, TW

Hepatocellular carcinoma is the third leading cause of cancer deaths in worldwide. In this study, multi-functional micelles loaded with doxorubicin (Dox) and labeled with the radionuclide rhenium-188 (188Re) were developed to provide the combination of [...]

Nanomaterials and nanotechnologies for the conservation of the materials of cultural heritage

Rathousky J., Kalousek V., Zouzelka R., J. Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, CZ

Conservation science is one of the most complex topics in the materials science as it requires expertise ranging from the history of art and archaeology to the advanced analytical and physical chemistry. However, the recent [...]

beta-casein micelles and nanocapsules in drug delivery

Khalfin R.L., Bachar M., Danino D., Technion – Israel Institute of Technology, IL

β-casein, the main protein found in milk, is an amphiphilic molecule that forms micelles both above and below the pI. In the presented work we investigated the possible use of β-casein micelles as a vehicle [...]

Thermoresponsive Magnetic Micelles for Simultaneous Magnetic Hyperthermia and Drug Delivery

Kim D-H., Elena R., Rajh T., Bader S.D., Novosad V., Argonne National Laboratory, US

Hyperthermia has been shown to be a potentially effective therapeutic modality in cancer treatment as it intensifies the efficacy of chemotherapy. The hyperthermia has a good synergic effect with chemotherapy. Their sensitivity to chemotherapy after [...]

pH-responsive self assemblies for “smart surface coatings”

Baquey G., Sakai K., Perrier S., Biggs S., Chamelic Ltd, UK

Over the last few years, adsorption of polyelectrolytes at solid/liquid interfaces has gained in popularity due to their potential applications for drug delivery, for the preparation of nanosized materials and for the fabrication of smart [...]

Growth Kinetics of Gold Nanoparticles in Reverse Micelles

Herrera A.P., Vicuña E., Rinaldi C., Castro M.E., Irizarry R., Briano J.G., University of Puerto Rico, US

Gold nanoparticles were formed from the reduction of gold (III) in reverse micelles and monitored with a stopped flow analyzer. The gold and the reducing agent micelles were formed in isooctane and AOT (as surfactant). [...]