mice – TechConnect Briefs

Gold nanoparticles caused learning impairment in mice

Chen Y-S, Hung Y.-C., Liau I., Lin L.-W., Hong M.-Y., Huang G.S., National Chiao Tung University, TW

Aims : To investigate the toxic effect of gold nanoparticles (GNP) to the learning and memory of mice. Key findings: Both 17 nm and 37 nm GNPs induced severe sickness in mice. However, only 17 [...]

New Applications of Nanoparticles in Cardiovascular Imaging

Sharma R.R., FAMU-FSU College of Engineering, US

Nanotechnology involves working at the atomic, molecular, and macromolecular levels including imaging. Recently, four areas have emerged in cardiovascular imaging:1.Targeted therapeutics: delivering drugs where they are needed; 2.Tissue engineering to replace defective valves, damaged heart [...]

A search of superparamagnetic iron oxide-myoglobin as potential nanoparticle based magnetic resonance imaging marker in mouse heart imaging

Sharma R., Haik Y., Chen C-J., FAMU-FSU College of Engineering, US

Superparamagnetic iron oxide (Fe2O3) has emerged as potential MRI contrast agent in whole animal imaging to localize the site of clinically important physiological damage such as ischemia, angiogenesis, oxygen insufficiency, immuno-deficiency [1, 2]. We achieved [...]

Molecular Targeted Functional, Cellular and Molecular Imaging of Atherosclerosis with Antibody-conjugated Superparamagnetic Particles Using Magnetic Resonance

Sharma R., Katz J.K., Haik Y., Chen C-J., FAMU-FSU College of Engineering, US

Background: Magnetic Resonance Imaging (MRI) is a powerful non-invasive technique that provides high-resolution anatomical images of biological tssue based on their inherent physio-chemical properties. The signal from MRI can be modulated by contrast agents, which [...]