membrane – Page 6 – TechConnect Briefs

MembraneChipTM : Arrays of Natively Displayed Membrane Targets for Novel Drug Discovery

Yamazaki V., Nguyen L.T., Schafer R.J., Ulman N., Groves J.T., Proteomic Systems, Inc., US

For the first time, naturally fluid and functional biological membranes have been integrated into a scaleable system. Previously-inaccessible membrane targets can be presented in their native environment. Domains of membrane targets naturally displayed in cell [...]

Modeling AFM Induced Mechanical Deformation of Living Cells

Rudd R.E., McElfresh M., Balhorn R., Allen M., Belak J., Lawrence Livermore National Laboratory, US

One challenge with using Atomic Force Microscopy (AFM) for recognition microscopy on living cells is the fact that the cell is not rigid, and as the force is applied to a receptor site, it is [...]

Computational Studies of Membrane-Based Test Formats

Krishnamoorthy S., Makhijani V.B., Lei M., Giridharan M.G., Tisone T., CFD Research Corporation, US

Membrane-based test formats provide simple, accurate and cost effective diagnoses of acute and chronic conditions in general population health. The sensitivity of the immunoassay is determined by the complex biochemical binding kinetics associated with the [...]

Finite-Element Modeling of 3C-SiC Membranes

DeAnna R.G., Mitchell J., Zorman C.A., Mehregany M., U.S. Army Research Laboratory, US

Finite-element modeling (FEM) of 3C-SiC thin-film membranes on Si substrates was used to determine the residual stress and center deflection with applied pressure. The anisotropic, three-dimensional model includes the entire 3C-SiC membrane and Si substrate [...]

Analysis of Unstable Behavior Occurring in Electro-Mechanical Microdevices

König E-R, Wachutka G., Münich University of Technology, DE

We analyze the instability which is inherent to electrostatically driven microdevices. Further, we propose a homotopy method to overcome this difficulty during simulation of these devices. Starting from a simplified model, the governing differential equations [...]