in vitro model – TechConnect Briefs

Dose- and Time-dependent Effects of Sub-chronic Functionalized MWCNT Exposure on Human Mesothelial Cell Neoplastic Transformation Potential

Stueckle T.A., Davidson D.C., Derk R., Gracheck P., Wu N., Rojanasakul Y., Wang L., National Institute for Occupational Safety and Health, US

Multi-walled carbon nanotubes (MWCNTs) are characterized by asbestos-like fiber morphology and surface chemistries. Physicochemical properties of MWCNTs that influence pleural mesothelioma potential are unknown, but critically needed to enhance safe-by-design nanotechnology. We hypothesized that surface [...]

In vitro Model for Identifying Subchronic Carbon Nanotube Exposure and Lung Cancer Gene Markers

Stueckle T., Davidson D., Derk R., Meighan T., Castranova V., Rojanasakul Y., Wang L., National Institute for Occupational Safety and Health, US

Concern for increased risk of carbon nanotube-associated lung disease, including carcinogenesis, has been raised due to asbestos-like characteristics. To date, no particle specific nanomaterial exposure or lung cancer markers have been identified. Here, we use [...]

In Vitro Assessment of Nano-Cerium Oxide (nCeO2) and Nano-Ferric Oxide (nFe2O3) on Fibrogenic and Carcinogenic Potential

Wang L., Davidson D., Stueckle T., Derk R., Chen M., Sotiriou G.A., Demokritou P., Luanpitpong S., Ma J., Mercer R.R., Castranova V., Rojanasakul Y., National Institute for Occupational Safety and Health, US

Goal of the present study is to investigate the specific cellular responses to nCeO2 and nFe2O3 in various lung cell types and develop an in vitro chronic exposure model to predict the potential fibrogenic and [...]