electrophoresis – Page 2 – TechConnect Briefs

Electrokinetic Instabilities and Sample Stacking

Lin H., Oddy M.H., Santiago J.G., Stanford University, US

Microfabrication technology has enabled the application of electrokinetics as a method of performing chemical analyses and achieving liquid pumping in electronically-controlled microchip systems with no moving parts. This talk reviews progress at Stanford in the [...]

Computational Analysis of On-line Coupled ITP-CE

Horner M., Fluent, Inc., US

Lab-on-a-chip technologies combine a sequence of chemical and/or biological analyses on a miniaturized platform to perform an analytical task or series of tasks. Lab-on-a-chip applications include chemical/biological agent detection, DNA sequencing/analysis, and drug discovery, to [...]

Strong DC and Low-Frequency AC Fields for the Manipulation of Particles and Fluids in Microfluidics

Kumar A., Qiu Z., Khusid B., Yeksel M., Acrivos A., New Jersey Institute of Technology, US

Electroosmosis and electrophoresis are considered to be the main phenomena for transport of aqueous liquids and particles in microfluidic devices because field-based techniques do not require any moving parts and can be incorporated more favorably [...]

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Tessier F., Slater G.W., University of Ottawa, CA

We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the [...]

Direct Numerical Simulation of Moving Charged, Flexible Bodies with Thermal Fluctuations

Patankar N.A., Northwestern University, US

The interaction of sub-micron scale objects with fluids is an important problem encountered in miniaturized systems. Various physical phenomena should be modeled simultaneously for a fundamental investigation of these systems. Our objective is to develop [...]

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Tessier F., Slater G.W., University of Ottawa, CA

We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the [...]

Modeling of Joule Heating in Electrophoretic Separation Microchips

Wang Y., Lin Q., Hoburg J.F., Mukherjee T., Carnegie Mellon University, US

This paper presents a model for Joule heating induced analyte dispersion in electrophoretic separation channels with a rectangular cross section. The model is in closed form and captures the effect of cross-sectional geometry. Three-dimensional numerical [...]

Electroosmotic Flow and Zone Broadening in Microfluidic Channels of Variable Cross-Section and Wall Charge

Ghosal S., Lu Z., Northwestern University, US

Electroosmotic flow is often the method of choice for generating fluid flows in micro fluidic devices. The resulting flow has a characteristic at profile which has the advantage of very low axial dispersion. This is [...]

Direct Numerical Simulation of Moving Charged, Flexible Bodies with Thermal Fluctuations

Patankar N.A., Northwestern University, US

The interaction of sub-micron scale objects with fluids is an important problem encountered in miniaturized systems. Various physical phenomena should be modeled simultaneously for a fundamental investigation of these systems. Our objective is to develop [...]

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Krishnamoorthy S., Feng J.J., Makhijani V.B., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]