drug delivery – Page 3 – TechConnect Briefs

Efficient drug delivery for cancer treatment using amine-functional SiO2-LDH nanocomposites

Li L., Liu J., Gu W.Y., Gu Z., Gu W.Y., Gu Z., Liu J., Xu Z.P., Australian Institute for Bioengineering and Nanotechnology, AU

Target-specific delivery and sustained release of anticancer agents and siRNA has attracted considerable research interest in cancer chemotherapy. Recently, we have developed layered double hydroxide (LDH) vector to efficiently deliver drug and siRNA into the [...]

Tracking Nanoparticles in Biological Fluids using Single Particle ICP-MS

Stephan C., Cirtiu C.M., PerkinElmer, CA

Single Particle-ICP-MS is a new operating mode in ICP-MS that is dedicated to the analysis of engineered nanoparticles (ENPs) commonly used in Nanomedicine and drug delivery systems. Single Particle (SP-ICP-MS) allows the differentiation between ionic [...]

Cu/TiO2-SiO2 Nanostructured Materials for Brain Cancer Treatment

Ortiz-Islas E., Guevara P., Gómez E., Monroy H., Novaro O., National Institute of Neurology and Neurosurgery, MX

In the present work, we are reporting the toxic effect to brain cancer cells exerted by copper complexes loaded (CC) on a binary oxide. For this purpose, the TiO2-SiO2 oxide was prepared using the sol-gel [...]

In Vitro Delivery of Docetaxel to Cancer Cells by Hybrid PLGA@Organosilica Nanoparticles with Redox-Sensitive Molecular Gates

Botella P., Quesada M., Vicente V., Cabrera A., Fabregat K., Instituto de Tecnologia Quimica (UPV-CSIC), ES

We have developed a novel hybrid material based in spherical PLGA nanoparticles containing hydrophobic molecules which have been covered by a thin layer (6-10 nm) of a redox-responsive amorphous organosilica shell. The outer layer incorporates [...]

Controlled Intracellular Release of Camptothecin by Glutathione-Driven Mechanism

Botella P., Muniesa C., Vicente V., Fabregat K., Cabrera A., Instituto de Tecnologia Quimica (UPV-CSIC), ES

Direct coupling of camptothecin (CPT) to nanoparticles is circumvented by the reduced therapeutic activity of its structure-modified derivatives. To negotiate this problem, we have developed a novel CPT nanoplatform based in a mercapto-functionalized silica hybrid [...]

pH Responsive Polymeric Nanoparticles Fabricated by Dispersion Polymerization as a Platform for the Delivery of Anticancer Drugs

Puri R., Berhe S., Akala E., Howard University, US

In diseased conditions such as tumors, pH is slightly more acidic than in the blood. The endocytic pathway of cells begin near the physiological pH of 7.4, but it drops to a lower pH of [...]

Reversing Coagulopathy and Internal Hemorrhage with Functionalized Nanoparticles

Kudela D., May-Masnou A., Smith S.A., Braun G., Pallaoro A., Chuong T., Morrissey J.H., Stucky G.D., University of Californi, Santa Barbara, US

Uncontrolled hemorrhage is a major cause of preventable death. Wound treatment focuses on using nanostructured oxide and clay-based materials to quicken clot formation. Internal injuries further complicate treatment due to inaccessibility. In response to severe [...]

Gold-based Nanostructures for Improved Cancer Therapeutics

Yang C., Neshatian M., Hegarty N., Chithrani D., Ryerson University, CA

The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in cancer therapeutics. Among other nanoparticle (NP) systems, there has been [...]

Development of Drug Delivery System Using Bio based Calcium carbonate Nanoparticles

Render D., Rangari V., Samuel T., Ramapuram J., Pawar K., Jeelani S., Tuskegee University, US

The CaCO3 nanoparticles were derived from egg shells using sonochemical and mechanochemical methods. The glycerol and acetic acid were used as solvents in this process to avoid other toxic solvents. These nanoparticles were loaded with [...]

Programming and switching the pharmacokinetics of nanoscale delivery vehicles in vivo

Chien M.-P., Gianneschi N.C., University of California San Diego, US

It has been shown that the morphology of nanomaterials greatly impacts the pharmacokinetic profile of the material, with larger micronscale fibril-like objects having longer circulation times while smaller nanomaterials show a greater rate of internalization [...]