drug delivery systems – TechConnect Briefs

Technological Challenges and Potential Advantages of Lipobeads as Drug Delivery Systems

Kazakov S., Pace University, US

Both polymeric and liposomal drug delivery systems tend to develop in the direction of increasing complexity, i.e. in accord with our understanding of the complex biological mechanisms prevailing in situ. To this point, one can [...]

Drug delivery system based on inorganic layered materials

Cunha V.R.R., Petersen P.A.D., Petrilli H.M., Constantino V.R.L., University of Sao Paulo, BR

Layered Double Hydroxides (LDHs) are well known inorganic carriers which have been explored during the development of new materials for medicinal and pharmacological applications. The solubility and chemical stability of guest species can be increased [...]

Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors

Lin C.Y., Shieh M.J., National Taiwan University, TW

In this article, we present pH-sensitive and small size nanoparticles as carrier to encapsulate 17-AAG. We anticipate that this platform will provide a new strategy for cancer therapy.

Synthesis and Characterization of Functionalized Magnetic Nanoparticles for Biomedical Applications

Wang L.F., Lo Y.L., Ke J.H., Kaohsiung Medical University, TW

One-pot synthesized polyacrylic acid-modified iron oxide (PAAIO) was decorated with a polymer, which was served as a reservoir for a therapeutic agent or a fluorescent dye via chemical or physical approaches. PAAIO possess specific magnetic [...]

Importance of Solid Lipid Nanoparticles in Cancer Therapy

Guney G., Kutlu H.M., Anadolu University, TR

A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anti- cancer drugs can be associated [...]

Modeling of Polymer-Drug Interactions in Biodegradable Tyrosine-Based Nanospheres Using Molecular Dynamics Simulations and Docking

Costache A.D., Sheihet L., Knight D.D., Kohn J., Rutgers University, US

The intensive labor and high cost of developing new vehicles for the delivery of drugs in a controlled manner, highlights the need for a change in their discovery process. Predictive computational models can be used [...]

Synthesis of magnetic nanoparticles and its applications in drug delivery systems

Wright Bolden N., Rangari V., Jeelani S., Tuskegee University, US

Summary An improved method of drug delivery is much needed in areas such as cancer therapy in which more drugs needs to be delivered to a specific site and non-specific toxicities should be minimal. Drug [...]

Nanotechnology in Pharmaceutical Education In USA

Pathak Y.V., Koomer A., Sullivan University College of Pharmacy, US

Nanotechnology is on its way to make a big impact in Biotech, Pharmaceutical and Medical diagnostics sciences. A dynamic collaboration is observed within the Researchers, Government, Pharmaceutical - Biomedical companies and educational institutions all over [...]

An implantable Drug Delivery Device based on MEMS

Elman N.M., Ho Duc H-L, Cima M.J., Massachusetts Institute of Technology, US

An implantable biochip based on MEMS (Micro-Electro-Mechanical-Systems) was developed to treat hemorrhagic shock in the battlefied. We discuss the design, fabrication, and testing of the device. In addition, we describe an animal model validating the [...]

Lipobeads as Drug Delivery Sysytems

Kazakov S.V., Levon K.M., Pace University, US

Nanoparticles have been extensively studied as drug delivery systems. In this presentation, we focus on a relatively new type of nanoparticles – lipobeads – a liposome-hydrogel assembly as a novel drug delivery system. Lipobeads are [...]