DNA – Page 8 – TechConnect Briefs

Structure and Environment Influence in DNA Conduction

Adessi Ch., Walch S., Anantram M.P., NASA Ames Research Center, US

Results for transmission through poly(G) DNA molecules are presented. We show that a modification of the rise of a B-DNA form can induce a shift of the conduction channel toward the valence one. We clearly [...]

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Jendrejack R.M., de Pablo J.J., Graham M.D., University of Wisconsin-Madison, US

Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coil size (~1 um for viral DNA) are quite different from those in free solution, because of [...]

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Tessier F., Slater G.W., University of Ottawa, CA

We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the [...]

DNA Machines for Molecular Self-Assembly

Simmel F.C., Yurke B., Bell Laboratories, Lucent Technologies, US

The molecular recognition properties of DNA are used to construct and power two prototype nanomachines, a pair of molecular tweezers and a nanoactuator. The motion of these machines is driven by hybridization with DNA "fuel" [...]

Simulation and Experimental Verification of Micro Polymerase Chain Reaction Chip

Lin Y-C., Yang C-C., Hwang M-Y., Chang Y-T., Cheng Kung University, TW

This study used finite element analysis to simulate the temperature characteristics of a micro polymerase chain reaction (PCR) chip. The micro-PCR chip was fabricated on a silicon wafer and Pyrex glass using photolithography, wet etching, [...]

Characterization of DNA Flow through Microchannels

Shrewsbury P.J., Muller S.J., Liepmann D., University of California-Berkeley, US

Advances in silicon fabrication technology enable the reproduction of laboratory apparatus, and theoretically biochemical processes, on a microscale. The implementation of this technology, however, necessitates additional study as fluid dynamics change at this scale and, [...]