DNA damage – TechConnect Briefs

Oxidatively Induced Damage to DNA: Potential Roles of Single- and Multi-Wall Carbon Nanotubes at the Molecular Level

Nelson B.C., National Institute of Standards and Technology, US

Carbon nanotubes (CNTs) are remarkable materials in terms of their enhanced thermal and electrical conductivities, tensile strengths and mechanical properties. Because of these unique properties, the commercial development and application of CNTs in electronics, advanced [...]

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

Petersen E.J., Marquis B.J., Jaruga P., Dizdaroglu M., Nelson B.C., National Institute of Standards and Technology, US

Determining the effects of various surface coatings on carbon nanotubes (CNTs) is critical given the numerous expected applications of CNTs and their inevitable release into ecosystems. To explore the potential ecotoxicological effects of CNT surface [...]

Mechanistic studies of in vitro cytotoxicity of PAMAM dendrimers in mammalian cells

Mukherjee S.P., Lyng F.M., Garcia A., Davoren M., Byrne H.J., Focas Research Institute, Dublin Institute of Technology, IE

The in vitro cytotoxic response of human dermal and colon cell lines to structurally well-defined full generation cationic dendritic polyamidoamine (PAMAM) nanoparticles of generations G4, G5, G6 was investigated. PAMAM dendrimers have been demonstrated to [...]