collagen – TechConnect Briefs

Electrospinning of collagen with nanocapsules of PLGA for delivery of paclitaxel in drug-eluting stents

Agudelo L.M., Cornelio J.A.C., Rodriguez L.F., Ortiz I.C., Hoyos L.M., Colmenares G.J., Universidad Pontificia Bolivariana, CO

Drug-eluting stents can facilitate a drug’s release directly to the specific site, but the main difficulty with drug-eluting stents is that the initial burst of drug release can extremely affect the pharmacological action and this [...]

ActiVlayr Nanofiber Technology

Hosie I., Revolution Fibres Ltd, NZ

Revolution Fibres Ltd is New Zealand’s premier advanced materials company and a global leader in nanofibre production. Its mission is to enable companies to produce superior products using Revolution Fibres technology for creating functional electrospun [...]

Carbon Nanotube-Collagen Scaffolds for Mesenchymal Stem Cells’ Differentiation: Changes in Alkaline Phosphatase Expression, Meneralizaton, and Energy Content

Bakture R., Kwon S., Sharma A., Sharma R., Sharma A., Sharma R., Utah State University, US

The applications of carbon nanotubes (CNTs) have tremendous potentials for them as substrates of cell cultures, drug delivery systems, and medical implantable materials. We characterized the energy simulations of different CNT-composite materials with the use [...]

Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent

Madhavan K., Belchenko D., Tan W., University of Colorado at Boulder, US

This study involves the mechanical and biological characterization of crosslinked collagen-based scaffolds for arterial medial-equivalent. These scaffolds are made from a mixture of collagen, chitosan and elastin and crosslinked with genipin. The method of optimization [...]

Nanocomposites based on Self-assembly of Collagen with DNA

Yadavalli V.K., Pidaparti R.M., Virginia Commonwealth University, US

Collagen is a fibrous protein that undergoes a complex self-organizing process at the nano-, micro-, and macro-scales to form hierarchical fibers. Fiber nano/microstructures are extremely sensitive to biophysical/biochemical environments. Their mechanical properties and anisotropy (macroscale) [...]

Atomic Force/Scanning Probe Microscopy of Pharmaceutical and Biological Materials

Chernoff D.A., Advanced Surface Microscopy, Inc., US

AFM is a valuable tool for a wide range of materials and device analysis. AFM images of particles and biopolymers are valued because direct visualization and measurement of individual objects complements the average measures obtained [...]

Exploring the behavior of concentrated collagen, approaches to tailor biomimetic materials

Gobeaux F., Mosser G., Anglo A., Panine P., Davidson P., Giraud-Guille M.-M., Belamie E., Ecole Pratique des Hautes Etudes, FR

Dense ordered collagen matrices can be obtained by fine tuning the electrostatic interactions in highly concentrated solutions of type I collagen. Such biomimetic fibrillar materials have a high application potential in the field of tissue [...]

Colloidal ß-TCP Facilitates Synthesis of Collagen Nano-composite

Shibata Y., Yamamoto H., Miyazaki T., Showa University, JP

Recently, hydroxyapatite/collagen composites have received much attention in the field of tissue reconstruction, because human bone is mainly composed of hydroxyapatite and collagen fibers. However, these composites cannot be synthesized without secondary treatments, therefore the [...]

Plasma-Treated and Collagen-Coated PLLA Nanofiber Membrane for Cartilage Tissue Engineering

Chen J.P., Lee S.F., Chiang I.P., Chang Gung University, TW

Biodegradable nanofiber membranes from poly-L-lactic acid (PLLA) were prepared by electrospinning to be used as a scaffold in cartilage tissue engineering. Parameters during the electrospinning process were studied in detail in terms of diameters of [...]