CFD-ACE+ – TechConnect Briefs

Analysis of Physico-Chemical Processes in an Amperometric Oxygen Biosensor

Krishnamoorthy S., Feng J.J., Makhijani V.B., Gao C., Choi J.W., Ahn C., CFD Research Corporation, US

Amperometric techniques are commonly used in lab-on-a-chip systems to sense various blood gas analytes such as H+, CO2, O2, etc. In the present study, a microchip-based amperometric biosensor, being developed as a part of plastic-based [...]

Simulation of Flow in Structurally Programmable Microfluidic Channels

Makhijani V.B., Reich A.J., Puntambekar A., Hong C., Ahn C., CFD Research Corporation, US

This paper describes the simulation of liquid filling in a structurally-programmable microfluidic delivery system being developed as part of a disposable biochip for clinical diagnostics. Flow control in the system is achieved by using passive [...]

Computational Design Analysis for In-Plane Microfluidic Valves

Dickey C.K., Makhijani V.B., Deshmukh A., Liepmann D., CFD Research Corporation, US

Simulations of fluid flow across in-plane microvalves were performed using an advanced multi-physics commercial software system and compared with experimental data. Model validation required careful consideration of leakage pathways left by fabrication artifacts. Following model [...]

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Krishnamoorthy S., Feng J.J., Makhijani V.B., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]