Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

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Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

Polymersomes as model of transcytosis across Blood-Brain Barrier (BBB)

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In this work, two formulations kinds of diblock copolymers ((poly(2- methacryloyloxy)ethyl phosphorylcholine)-co-poly(2-(diisopropylamino)ethyl methacrylate(PMPC25-­‐PDPA70) and poly(ethylene glycol)-co-poly(2- (diisopropylamino)ethyl methacrylate)(PEO113-­‐PDPA70))will be employed,blending them in series ratios in order to obtain the best morphology and size across the [...]