blood brain barrier – TechConnect Briefs

Nanodelivery of drugs for therapeutic strategies in CNS disorders. Current and Future perspectives

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Nanodelivery of drugs, diagnostic agents and other functionalized nanoparticles aiming for better treatment of diseases or diagnosis purposes are the new trends in medicine that appear promising. However, nanoparticles or nanotechnology used to deliver these [...]

Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

‘Sink effect’ of dually-decorated nanoliposomes on Abeta clearance

Re F., Minniti S., Bana L., Masserini M., Re F., University Milano Bicocca, IT

Plaques containing beta-amyloid peptides are one of the hallmarks of Alzheimer’s disease (AD) and the reduction of Abeta is considered a primary therapeutic target. Recently, strategies have been employed to reduce Abeta brain levels and [...]

NAD-Nanoparticles for Therapy and Diagnosis of Alzheimer Disease

Masserini M., Gregori M., Salvati E., Re F., Masserini M., University Milano Bicocca, IT

NAD project (large cooperative; 19 partners, funded by the E.C.) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by synthesis of multiple-functionalized nanoparticles, able to bind, detect and remove Abeta from [...]

Polymersomes as model of transcytosis across Blood-Brain Barrier (BBB)

Tian X., Cantón I., Battaglia G., Univ of Sheffield, UK

In this work, two formulations kinds of diblock copolymers ((poly(2- methacryloyloxy)ethyl phosphorylcholine)-co-poly(2-(diisopropylamino)ethyl methacrylate(PMPC25-‐PDPA70) and poly(ethylene glycol)-co-poly(2- (diisopropylamino)ethyl methacrylate)(PEO113-‐PDPA70))will be employed,blending them in series ratios in order to obtain the best morphology and size across the [...]

Invention of Polysaccharide-base Nanoparticles for Enhancing Drug Permeability across the Blood Brain Barrier

Gil E.S., Lowe T.L., Pennsylvania State University, US

The primary objective of this study is to evaluate novel cationic and degradable beta-cyclodextrin nanoparticles as drug delivery carriers for insulin across the bovine brain microvessel endothelial cell (BBMVEC) monolayer, an in vitro blood brain [...]