Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo

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In the last decade, the development of targeted drug delivery with conjugated nanoparticles brings more drug molecules to the diseased sites, at the same time reducing a systemic drug exposure. Polyethylene glycol (PEG) conjugation is [...]

In vitro Model for Identifying Subchronic Carbon Nanotube Exposure and Lung Cancer Gene Markers

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Concern for increased risk of carbon nanotube-associated lung disease, including carcinogenesis, has been raised due to asbestos-like characteristics. To date, no particle specific nanomaterial exposure or lung cancer markers have been identified. Here, we use [...]