biomarkers – TechConnect Briefs

Functionalized Carbon Nanotube-based Microelectronic Sensor Array for Early Diagnosis of Alzheimer’s Disease

Johnston A.S., Tang Y., Alam M.M., InnoSense LLC, US

We designed and developed a lab-on-a-chip for the early diagnosis of Alzheimer’s Disease (AD) based on our patent-pending innovative nanotechnology by utilizing patterned microelectronic sensor devices for detecting Food and Drug Administration (FDA)-approved AD biomarkers [...]

Quantitative Electrolateral Flow Immunosensor (ELLI): Dengue Triage and Stroke Prognosis Case Studies

Sinawang P.D., Fajs L., Marks R.S., Ben-Gurion University of the Negev, IL

The development of a rapid, affordable, and sensitive diagnostic kit for point-of-care is important in most healthcare settings; however, only a few exhibit the needed quantitative capability. Our technology, ELLI, is a patented diagnostic device [...]

Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo

Kоbylinska L., Panchuk R., Skorohyd N., Senkiv Y., Heffeter P., Berger W., Boiko N., Mitina N., Zaichenko A., Lesyk R., Zіmenkovsky B., Stoika R., Vari G.S., Danylo Halytsky Lviv National Medical University, UA

In the last decade, the development of targeted drug delivery with conjugated nanoparticles brings more drug molecules to the diseased sites, at the same time reducing a systemic drug exposure. Polyethylene glycol (PEG) conjugation is [...]

Towards Medical Diagnostics Using Hyperspectral X-ray Scatter

Greenwood C., Rogers K., Wilson M., Lyburn I., Evans P, Davies G., Cranfield University, UK

This pilot study builds from a recent international, programme that showed, for the first time, the clinical value of new biomarkers to predict fracture risk in osteoporotic patients. The research indicated several potential, high impact [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

In vitro Model for Identifying Subchronic Carbon Nanotube Exposure and Lung Cancer Gene Markers

Stueckle T., Davidson D., Derk R., Meighan T., Castranova V., Rojanasakul Y., Wang L., National Institute for Occupational Safety and Health, US

Concern for increased risk of carbon nanotube-associated lung disease, including carcinogenesis, has been raised due to asbestos-like characteristics. To date, no particle specific nanomaterial exposure or lung cancer markers have been identified. Here, we use [...]

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Gold Nanoparticle Chemiresistors as a Generic Platform for Sensing

Chow E., Raguse B., Wieczorek L., Cooper J.S., Hubble L.J., Webster M.S., Müller K.-H., CSIRO, AU

Thiol-functionalised gold nanoparticle chemiresistors can respond to low-molecular weight chemicals through changes in electrical resistance. This low-cost sensor technology is currently being developed for multiple applications including water quality, microbial metabolomics, environmental monitoring, and point-of-care [...]

Ultralow Detection of Bio-markers using Gold Nanoshells

Patel D., Zhang G., Sun X., Gobin A.M., Keynton R.S., University of Louisville, US

The focus of this project is to improve the detection of antigen/biomarkers/viral vectors using gold nanoshells (GNS). The assay used in this project is based on aggregation of GNS in presence of antigen or viral [...]

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]