biomarker – TechConnect Briefs

Influence of metallic, ceramic, and plastic MALDI surface materials on the ionization efficiency and quality of mass spectrometric data

Hieke A., Stanford University, School of Medicine, US

Imperfections of the MALDI ionization process of proteins and peptides impose considerable limitations on the utility of mass spectrometry in basic life sciences and ultimately on the application in biomarker discovery and medical diagnostics. Improved [...]

Investigating the role of the FOXA1 protein in cancer with Scanning Probe Microscopy

Theodorou I., Imperial College London, UK

The FOXA1 protein has generated considerable interest for its use as a biomarker in breast cancer. In this project, the binding kinetics of FOXA1 with the BRCA1 and FOXC2 are investigated using Scanning Probe Microscopy. [...]

Ferromagnetic Resonance Biochip for Diagnosing Pancratic Cancer

Casler E., Chae S., Kunduru V., Bothara M., Yang E., Ghionea S., Dhagat P., Prasad S., Portland State University, US

The goal of this research is to be able to develop a device that would be able to detect and diagnosis pancreatic cancer at bedside. The key criteria to be addressed are the cost, portability, [...]

‘Lab on a chip’ Label Free Protein Sensor Systems Based on Polystyrene Bead and Nanofibrous Solid Supports

Kunduru V., Prasad S., Patra P.K., Sengupta S., Portland State University, US

Polystyrene bead and electrospun polystyrene nanofibers are employed as subjects of study in this protein biomarker sensor. The study is conducted to compare the sensitivity and efficiency of the polystyrene nanofibers and microspheres as protein [...]

Enrichment of serum phosphopeptide by nanoparticles to identify cancer biomarker

Shah A., Sachdev V., Bharti A., Boston University Medical School, US

The role of kinases in transformation and cancer progression is established. We hypothesize that The role the specific phosphoproteins/phosphopeptides will be present in cancer patient serum as leak proteins and their isolation and identification will [...]

Gold Nanoparticle Bioconjugates for Biomolecular Imaging and Detection

Liu X., Dai Q., Coutts J., Austin L., Knowles G., Huo Q., University of Central Florida, US

Gold nanoparticles and colloids have been used for a long time in biomolecular imaging and detection. With further understanding on many of the electrical and optical properties of gold nanoparticles revealed recently, the application of [...]

Devices for Nanoparticle-based Cancer Detection

Kim G.Y., Daniel K.D., Vassiliou C.C., Elman N., Josephson L., Cima M.J., MIT, US

This implantable biomarker sensor combines nanoscale magnetic relaxation switches (MRSW) and the versatility of microfabricated structures tp be read by MRI. MRSW are magnetic iron oxide nanoparticles that can be functionalized to detect a variety [...]

Nanoparticle Labels/ Electrochemical Immunosensor for Detection of Biomarkers

Liu G., Wang J., Lin Y., Pacific Northwest National Lab, US

A sensitive electrochemical immunoassay based on nanoparticle labels has been developed for the detection of protein biomarker-Macrophage chemoattractant protein 1.The approach is based on a new biosensing principle of the protein biomarker-induced formation of nanoparticles [...]

Functional Nanoarrays for Protein Biomarker Profiling

Lynch M., Mosher C., Huff J., Nettikadan S., Xu J., Henderson E., BioForce Nanosciences, Inc., US

The success of microarrays for analyzing nucleic acid and, more recently, protein-protein interactions illustrates the advantages of bioassay miniaturization. However, the current level of miniaturization of useful bioanalytical tools still creates limits in terms of [...]