Wu D. – TechConnect Briefs

Utility of Customized Targeted PEG Linkers for the delivery of oligonucleotides without the use of transfection reagents

Zhao H., Reddy P., Xia J., Wang M., Sapra P., Bandaru R., Belen Rubio M., Wu D., Zhu P., Filpula D., Greenberger L.M., Horak I.D., Enzon Pharmaceuticals, Inc., US

Delivery of LNA oligonucleotides using Customized Targeted PEG linkers has improved the in vitro cellular uptake into cancer cells. Customized Targeted PEG linker-LNA conjugates can knock down target mRNA in a concentration dependent fashion with [...]

Nanobiodevices Integrating Biomolecular Motors

Ramachandran S., Wu D., Nitta T., Tucker R., Phillips A., Hess H., University of Washington, US

Biomolecular motors, such as the motor protein kinesin, can serve as force-generating modules in hybrid nanodevices. We will present recent progress in utilizing these motors for nanoscale transport of target reagents and discuss applications, such [...]