Sharma R. – Page 5 – TechConnect Briefs

2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET

Sharma A., Sharma R., Sharma A., Sharma R., University of North Carolina, US

2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]

Bacterial Drug Delivery Systems and nanoparticles

Sharma R., Haik Y., UNCG, US

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Particles as Protein Markers: Nanoscale Microscopy Towards Picoscale

Shriniwas B.D., Sharma A., Sharma R., Sharma A., Sharma R., Chen C-J., Baile V.V., Raghukumar V., RTM Nagpur University, IN

The present report shows the emerging trend of picotechnology in bioengineering, Heteropneustes fossilis fish protein characterization by PAGE-gel electrophoresis, 10-100 nm nanoadducts by electron microscopy with possibility of nanogel-peptide(polyacylate-polyethylene-iron oxide) adducts as predictors of fish [...]

Search of Troponins as Smart Biosensors for Point-of-care Detection of Acute Myocardial Infarction

Sharma R., Florida State University, US

Troponin molecules and their T, C and I subtypes have shown significance in early point-of-care assessment of acute myocardial infarction. Other slowly released proteins are Creatine kinase MB, Fatty acid-binding Protein and myoglobin. Conventional antibody-antigen [...]

Interaction of carbon nanotube material with rat skin by 21 T MRI

Sharma R., Shetty K., Liang R., Chen C-J., Florida State University, US

Carbon nanotubes are emerging as potential tools in drug delivery nanocarriers to target specific cell types and carbon cages filled with metal molecules and may improve MRI microimaging. The present paper reviews the current state [...]

Are Emerging Applications of Carbon Nanotubes Safe?

Sharma R., Shetty K., Liang R., Chen C-J., Florida State University, US

Carbon nanotubes are emerging as potential tools in drug delivery nanocarriers to target specific cell types and carbon cages filled with metal molecules may improve MRI microimaging. The present paper reviews the current state of [...]

Nitrosyl-iron Complexes as Potent Smart Nitric Oxide Biosenors: MRI imaging Techniques in Progress

Sharma R., Kwon S., Florida State University, US

Nitric oxide is a gaseous, free radical which plays a role as a diffusible intracellular second messenger. It is emerging as biosensor for monitoring myocardial ischemia and the effect of HMG-CoA reductase inhibitor statins. Presently, [...]

Role of immunoregulators as possibility of tumor hypoxia-induced apoptosis

Sharma R., Kwon S., Chen C-J., Columbia University, US

IL-1, TNF-α and INF-γ cytokines stimulate in nitric oxide production and result with inflammation manifested by apoptosis and hypoxia. We propose that extent of inflammation leading to hypoxia initially and programmed cell death later both [...]

A search of superparamagnetic iron oxide-myoglobin as potential nanoparticle based magnetic resonance imaging marker in mouse heart imaging

Sharma R., Haik Y., Chen C-J., FAMU-FSU College of Engineering, US

Superparamagnetic iron oxide (Fe2O3) has emerged as potential MRI contrast agent in whole animal imaging to localize the site of clinically important physiological damage such as ischemia, angiogenesis, oxygen insufficiency, immuno-deficiency [1, 2]. We achieved [...]

Molecular Targeted Functional, Cellular and Molecular Imaging of Atherosclerosis with Antibody-conjugated Superparamagnetic Particles Using Magnetic Resonance

Sharma R., Katz J.K., Haik Y., Chen C-J., FAMU-FSU College of Engineering, US

Background: Magnetic Resonance Imaging (MRI) is a powerful non-invasive technique that provides high-resolution anatomical images of biological tssue based on their inherent physio-chemical properties. The signal from MRI can be modulated by contrast agents, which [...]