Sai V.V.R. – TechConnect Briefs

Transformation of gold nanoparticles into effective gene silencing vectors by oligoethylene glycol passivation

Papasani M.R., Pokharel D., Giri A., Sai V.V.R., Hrdlicka P.J., Hill R.A., University of Idaho, US

Small interfering RNAs (siRNAs) are useful agents for gene knockdown. We have taken a systematic approach to investigate the use of GNP as delivery platforms for firefly luciferase (FFL) siRNAs and the effect of passivation [...]

Novel Nanoprobes to Detect mRNA in situ Directed Against Mouse Pyruvate Dehydrogenas

Cheguru P., Østergaard M., Papasani M.R., Sai V.V.R., Wengel J., Hrdlicka P.J., Hill R.A., University of Idaho, US

Novel nanoscale synthetic locked nucleic acid (LNA) probes incorporating molecular beacon (MB) technology were developed. These novel MBs contained 2’-N-(pyren-1-yl)carbonyl-2’-amino-LNA monomers incorporated in the loop region. Specificity and sensitivity of MB designed to target the [...]

Nanoparticle-coated nanosprings for diagnostic applications using SERS based detection

Sai V.V.R., University of Idaho, US

Significant enhancements in the SERS signals may be obtained with elongated arrangement of silver or gold nanoparticles. Silica nanosprings (NS) with high surface to volume ratio are promising candidate to yield such sensor materials. In [...]