Pappaert K. – TechConnect Briefs

3-Dimensional Diffusion-Reaction Model for DNA Hybridization on Microarrays

Pappaert K., Baron G.V., Desmet G., Free University of Brussels, BE

Molecular diffusion limits the hybridization rate in microarrays, leading to overnight waiting times. During the last couple of years a large number of methods were developed to overcome this diffusion-limitation and to enhance the speed [...]

Enhancement of DNA Microarray Hybridization using Shear-Driven Microfluidics

Vanderhoeven J., Pappaert K., Dutta B., Vanhummelen P., Baron G.V., Desmet G., Free University of Brussels, BE

On microarrays the transport of the target molecules towards the spots only occurs by molecular diffusion. As a result, microarray analyses require overnight incubation and are highly inefficient in terms of capture rate and detection [...]