Holmes J.D. – TechConnect Briefs

Dendrigraft Poly-L-lysine (d-PLL) Coated Gold Nanoparticles in Water for siRNA Delivery to Prostate Cancer Cells

Rahme K., Minassian G., Ghanem E., Souaid E., Guo J., O’Driscoll C.M., Holmes J.D., Notre Dame University (Louaize), LB

In this study we used dendrigraft poly-L-lysine (d-PLL) as a stabilising ligand for gold nanoparticles (AuNPs) in water. The d-PLL generation two (P2) with narrow molecular weight distribution of about 7 KD was obtained by [...]

A Simple Synthesis of Polymer Coated Gold and Silver Nanoparticles in Water for Potential Use in Biomedical Applications

Rahme K., Minassian G., Ghanem E., Sarkis M., Nakhl M., El Hage R., Souaid E., Holmes J.D., Notre Dame University (Louaize), LB

Herein we describe a simple method for the synthesis of highly stable gold (Au) and silver (Ag) nanoparticles (NPs) in water. Ag and Au NPs of different surface charges (positively charged, negatively charged, or nearly [...]

Branched PEI Capped Gold Nanoparticles in Water for siRNA Delivery to Cancer Cells

Rahme K., Guo J., Biswas S., O’Driscoll C.M., Holmes J.D., Notre Dame University (Louaize), LB

Herein we describe a simple method for the synthesis of different sizes of polyethylenimine-capped gold nanoparticles (AuNPs-PEI) in water and assess their potential to deliver siRNA or other therapeutic agents to cancer cells. AuNP-PEI with [...]

Colloidal Palladium Nanoparticles versus Commercial Palladium Catalysts for Suzuki Cross Coupling Reactions – The Influence of Surface Functionalization

Collins G., ODywer C., Holmes J.D., University College Cork and Tyndall National Institute, IE

The Suzuki-Miyaura reaction is a highly utilised reaction for aryl-aryl bond formation in organic synthesis due it is versatility. The motivation for the application of heterogeneous catalysts in these systems is the easy recovery and [...]

Hydroxylamine-O-sulfonic acid as a New Reducing Agent for the Formation of Nearly Monodisperse Gold Nanoparticles in water: Synthesis Characterisation and Bioconjugation

Rahme K., Holmes J.D., Notre Dame University (Louaize), LB

Gold nanoparticles (Au NPs), with diameters ranging between 60-150 nm, have been synthesised in water at room temperature by reducing HAuCl4.3H2O with hydroxylamine-o-sulfonic acid in the presence of sodium citrate, as stabilising agent. 15 and [...]

AuxAg1-x alloy seeds: A way to control growth, morphology and defect formation in Ge nanowiress

Biswas S., Holmes J.D., University College Cork, IE

Ge nanowires are of current interest for high speed nanoelectronic devices due to the lower band gap and high carrier mobility and larger excitonic Bohr radius of Ge yields a more pronounced quantum confinement effect.Most [...]

Highly Stable PEGylated Gold Nanoparticles in water: Applications in biology and catalysis

Rahme K., Nolan M.T., Doody T., McGlacken G.P., O’Driscoll C., Holmes J.D., Notre Dame University (NDU), LB

Gold nanoparticles (Au NPs) with diameters ranging between 5-60 nm have been synthesised in water. Functionalised polyethylene glycol-based thiol polymers (mPEG-SH) were used to stabilise the pre-synthesised Au NPs. The grafting density of different PEG [...]

Growth of Carbon Nano-Structures in Ceramic Materials

Kufazvinei C., Leahy R.W., Lipson S.M., Blau W.J., Dillon F.C., Spalding T.R., Morris M.A., Holmes J.D., Allan G., Patterson J., Trinity College Dublin, IE

The investigation aims at growing carbon nanotubes of controlled diameter from inside pores of ceramic materials. The resulting carbon nanotubes will then be used in electrons as thermally conductive substrates in die mountings.

Conductive Films of Ordered High-Density Nanowire Arrays

Kulkarni J.S., Daly B., Ziegler K.J., Crowley T., Erts D., Polyakov B., Morris M.A., Holmes J.D., University College Cork, IE

We have prepared high-density, ordered arrays of semiconductor nanowires within the pores of mesoporous thin films (MTFs) and anodized aluminum oxide (AAO) matrices using a supercritical fluid solution-phase inclusion technique. Conductive atomic force microscopy (C-AFM) [...]