Gobin A.M. – TechConnect Briefs

Targeted Cancer Therapy by Immunoconjugated Gold-Gold Sulfide Nanoparticles Using Protein-G as a Cofactor

Sun X.H., Zhang G.D., Patel D., Gobin A.M., University of Louisville, US

Gold-gold sulfide nanoparticle (GGS-NP) with controllable near infrared (nIR) absorption was synthesized from a simple reaction of chloroauric acid and sodium thiosulfate. Through PEGylated recombinant Protein-G (ProG), ProG-conjugated GGS-NPs for antibody capture by Fc domain [...]

Ultralow Detection of Bio-markers using Gold Nanoshells

Patel D., Zhang G., Sun X., Gobin A.M., Keynton R.S., University of Louisville, US

The focus of this project is to improve the detection of antigen/biomarkers/viral vectors using gold nanoshells (GNS). The assay used in this project is based on aggregation of GNS in presence of antigen or viral [...]

A Novel High Yield Process for Gold Sulfide Nanoparticle Synthesis via Shifting Equilibrium of Self-Assembly Reaction

Patel D., James K., Zhang G., Gobin A.M., University of Louisville, US

This project is focused on the scale up of gold-gold sulfide (GGS) nanoparticles with desired near infrared peak (nIR) that can be used for therapeutic applications. By combining published methods for 1-step self-assembly of GGS [...]

Gold nanoshells aided optical imaging in vitro, in vivo and ex vivo

Lee M., Loo C., Gobin A.M., West J., Halas N., Drezek R., Korea Electronics Technology Institute, KR

Scattering-based optical imaging technologies such as Optical Coherence Tomography (OCT) and Reflectance Confocal Microscopy (RCM) offer a unique non-invasive approach to the detection, diagnosis, and monitoring of cancer. In this article, we describe the use [...]