Giri A. – TechConnect Briefs

Anti-K-Ras siRNA to Treat Pancreatic Cancer

Julien D.C., Giri A., Papasani M., Murdoch G., Hrdlicka P., Hill R.A., University of Idaho, US

Cancer of the pancreas is a leading cause of cancer-related mortality. Chemotherapeutic drugs used to treat pancreatic cancers are toxic and minimally effective, yielding a 1-4% 5-year survival rate after initial diagnosis. Approximately 90% of [...]

Transformation of gold nanoparticles into effective gene silencing vectors by oligoethylene glycol passivation

Papasani M.R., Pokharel D., Giri A., Sai V.V.R., Hrdlicka P.J., Hill R.A., University of Idaho, US

Small interfering RNAs (siRNAs) are useful agents for gene knockdown. We have taken a systematic approach to investigate the use of GNP as delivery platforms for firefly luciferase (FFL) siRNAs and the effect of passivation [...]