Accurate High-throughput Gene Synthesis Using Programmable DNA Microfluidic Microchips
Tian J., Gong H., Sheng N., Zhou X., Gulari E., Gao X., Church G.M., Harvard Medical School/Genetics, US
Testing the deluge of hypotheses flowing from genomics and systems biology demands accurate and cost-effective gene and genome synthesis. Here we describe a microchip-based technology for multiplex gene synthesis. Pools of thousands of "construction" oligonucleotides [...]