Bhushan A. – Page 2 – TechConnect Briefs

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes in Dorsal Root Ganglion (DRG) Neurons

Lai J.C.K., Gao W., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Because of their unique physico-chemical properties, carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications. Their escalating uses in multiple industries result in enhanced occupational human exposure to CNTs. However, the [...]

Molecular Effects of Silicon Dioxide Nanoparticles on Cell Survival Signaling of Dorsal Root Ganglion (DRG) Neurons and Schwann Cells

Jain A., Jaiswal A.R., Lu S., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

The molecular mechanisms underlying the pathophysiology of peripheral neuropathies have not been fully elucidated. To meet the need for suitable cell culture models in vitro of peripheral nervous system (PNS) neural cells that allow long-term [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]

Differential Cytotoxic Effects of Titanium Oxide Nanoparticles on Peripheral Nervous System Neural Cells

Lu S., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University College of Pharmacy, US

The health impact of exposure to TiO2 nanoparticles is poorly documented although exposure to the particles is known to elicit inflammatory responses in lung tissue. We recently found treatment with TiO2 micro- or nanoparticles induce [...]

New in Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone ( PPAR gamma agoinst) Offers Neuroprotection Against Nanoparticle-Induced Cytotoxity

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Recently, we and others have developed several cell models for the investigation of the molecular mechanisms underlying the cytotoxicity of nanoparticles of several metallic and non-metallic oxides. These important findings have raised the awareness for [...]

Elucidation of Neuroprotective Properties of Astrocytoma (Astrocytes-like) Cells in Neural Cell Culture Models In Vitro: Applications in Tissue Engineering and Nanotoxicology

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Evidence is accumulating that cell culture models in vitro facilitate high throughput and mechanistic studies in tissue engineering. We have developed several cell models for the systematic investigation of molecular mechanisms underlying the putative cytotoxicity [...]

A Non-contact Co-Culture Model of Peripheral Neural Cells for Nanotoxicity, Tissue Engineering and Pathophysiological Studies

Jaiswal A., Wong Y.Y.W., Bhushan A., Daniels C., Lai J.C.K., Idaho State University, US

Cell culture models in vitro have long served as tools for the elucidation of pathophysioligcal cellular and molecular mechanisms of diseases. Recently these versatile model systems have permeated into toxicology and tissue engineering research. Although [...]

Chitosan Membrane in Combinations with Nanoparticles and Adriamycin as a Treatment to Inhibit Glioma Growth and Migration

Leung S.W., Gao W., Gu H., Bhushan A., Lai J.C.K., Idaho State University, US

Our previous and on-going studies indicated that U87 cells cultured on chitosan film/membrane exhibited significantly slower growth and proliferation kinetics compared to U87 cells cultured in the absence of chitosan film/membrane. Chitosan exhibits anti-microbial activities [...]

Chitosan Film/Membrane as a Surface to Alter Brain Glioma Growth and Migration

Gao W.J., Wang Y.-H., Gu H.-Y., Jandhyam S., Dukhande V.V., Lai J.C.K., Lai M.B., Leung S.W., Bhushan A., Lai J.C.K., Lai M.B., Idaho State University, US

A hydrophilic polysaccharide derived from chitin, chitosan has gained increasing popularity in biomedical applications such as tissue engineering, wound dressing, and drug delivery because of its presumed biocompatibility. These applications were founded on chemical similarities [...]

Cytotoxicity of metallic oxide nanoparticles in human neural and non-neural cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

The use of nanomaterials in industrial applications (e.g., drug delivery, additives to drugs and cosmetics) has escalated in the last decade, leading to the possibility of their becoming environmental pollutants. However, these cytotoxic and other [...]