Bhushan A. – TechConnect Briefs

Enhancement of Effects of Chitosan and Nanoparticles on Pancreatic Cancer Cells by Combination Treatments with the Anti-Cancer Drug Adriamycin

Lai J.C.K., Gao W., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Because of chitosan’s roles in biomedical applications, this study investigated the effects of chitosan, chitosan in combination with silver or gold nanoparticles, and chitosan with nanoparticles and Adriamycin, Methotrexate or Cisplatin on human PANC-1 pancreatic [...]

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes on Pancreatic Cancer Cells

Lai J.C.K., Desai V., Zhang Y., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Although carbon nanotubes (CNTs) are increasingly exploited in diverse industrial and biomedical applications, their health hazard to humans is poorly understood. We have developed many cell models in vitro to systematically study the putative cytotoxicity [...]

Co-Culturing Dorsal Root Ganglion Neurons with Schwann Cells Protects Them Against the Cytotoxic Effects of Silver Nanoparticles

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Because of their presumed inertness, silver nanoparticles are increasing employed in many consumer products. Nonetheless, their environmental and health hazard impact are not understood. Our previous studies led us to develop a co-culture model consisting [...]

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Human Neuroblastoma and Astrocytoma Cells

Lai J.C.K., Lai M.B., Balaraju A.K., Neti A., Lai J.C.K., Lai M.B., Tadinada S.M., Idikuda V.K., Singh M.R.M., Mukka K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Because of their escalating uses in industrial and biomedical applications, humans are increasing exposed to nanoparticles in occupational and other environmental settings. However, the environmental safety and health impact of such particles have not been [...]

Cytotoxic Effects of Silver and Gold Nanoparticles in Human Glioblastoma U87 Cells

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Nanoparticles have contributed significantly to the design of new drug delivery and targeting in cancer chemotherapy. Consequently, some of the desirable qualities of silver and gold nanoparticles have prompted their novel applications in cancer nanobiotechnology. [...]

Entry of Short Multi-Wall Carbon Nanotubes into Dorsal Root Ganglion (DRG) Neurons Induces Cell Death

Lai J.C.K., Gao W., Bhushan A., Bearden S.E., McDougall L., Leung S.W., Idaho State University College of Pharmacy, US

Carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications because of their unique physico-chemical properties. However, the human health impact of exposure to CNTs is unknown. Our recent and ongoing studies [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US

Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]

Cytotoxic Effects of Four Metallic Oxide Nanoparticles on Dorsal Root Ganglion (DRG) Neurons

Lu S., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Metallic oxide nanoparticles have diverse industrial applications because of their exploitable physico-chemical and other properties. Consequently, the occupational environmental exposure of humans to these nanparticles is increasing; however, the health impact of their exposure has [...]

Cytotoxicity of Magnesium Oxide Nanoparticles in Schwann Cells

Idikuda V.K., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Diverse applications of metal oxide nanoparticles in various industries have been accelerating in the last decade. Magnesium oxide (MgO) nanoparticles have been employed in ceramics, and as adhesive and additive in chemical raw materials, leading [...]