University of Michigan – Page 2

A pbpk model to elucidate processes governing distribution and excretion of polyacrylamide nanoparticles

Wenger Y., Jolliet O., Schneider R., Philbert M., University of Michigan, US

This paper presents a physiologically based pharmacokinetics model that has been calibrated using experimental measurements of biodistribution and excretion of polyacrylamide nanoparticles in rats. The model is capable of establishing the complete mass balance of [...]

Wireless Integrated MicroSystems (WIMS): Coming Revolution in the Gathering of Information

Wise K.D., University of Michigan, US

This paper discusses recent developments in microsystems, including progress in low power sensing, circuit integration, wireless interfaces, and wafer-level packaging. Increasingly, such systems are realized on two or three chips in stacked configurations or embedded [...]

Nanoscale Analysis of Bone Mineral Crystals

Chen H., Robinson C., Shore R.C., Brookes S.J., Zhang J., Smith D.A., Clarkson B.H., Kirkham J., University of Michigan, US

The mineral component of both bones and teeth comprises of crystals of calcium hydroxyapatite. However, there are very few studies which have characterised and compared individual crystals from these mineralised tissues at the nanoscale. In [...]

Mixed-Domain Simulation of Step-Functional Voltammetry with an Insoluble Species for Optimization of Chemical Microsystems

Martin S.M., Strong T.D., Gebara F.H., Brown R.B., University of Michigan, US

Microinstruments with integrated sensors and electronics are well adapted for remote environmental monitoring applications. Optimization of these microinstruments, however, has been difficult due to a previous lack of mixed-domain simulation environments. This work presents a [...]

Molecular Dynamics Studies on Folic Acid and Fluorescein-Derivatized PAMAM Dendrimers

Lee I., Athey B.D., Wetzel A.W., Baker Jr. J.R., University of Michigan, US

Molecular dynamics simulations on PAMAM dendrimers were performed to design and optimize the condition for cancer cell targeting and imaging. Folic acid and fluorescein-conjugated dendrimers with a primary amine surface group (without capping) and with [...]

Optimal Design of Computer Experiments for the Generation of Microsystem Macromodels Using IMSET and Non-Parametric Fitting

Crary S.B., Cousseau P., Armstrong D., Woodcock D.M., Dubochet O., Lerch P., Renaud Ph., University of Michigan, US

We present a new and unique software program, IMSET, capable of finding optimal designs for computer experiments. A finite-element simulation of a micro-machined flow sensor was used to illustrate macromodel generation and to compare the [...]

Simulation of Electrothermal MOS Circuits Using Saber

Liu C.C., Carlen E.T., Wise K.D., Mastrangelo C.H., University of Michigan, US

In this paper we present a simple methodology for simulating small to medium sized circuits where electrical and thermal equations are solved simultaneously using Saber, a commercial, general purpose simulator. Dynamic electrothermal models have been [...]

A Least Squares Algorithm for Optimal Heater Placement in Microsensors

Liu C.C., Man P.F., Mastrangelo C.H., University of Michigan, US

In this paper we present an algorithm that yields the optimal placement of a finite number of constant power density heaters for an arbitrary desired temperature profile. Using this algorithm, the volume efficiency (the percentage [...]