Université de Rouen – TechConnect Briefs

Preparation And Evaluation Of In Vitro Release Of Amphiphilic _-Cyclodextrin Or Pla Nanospheres Containing A Hydrophobic Drug

Lin S., Lahiani-Skiba M., Naouli N., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

Mebendazole (MBZ) is an antihelmintic which belongs to group of benzimidazols. It is used for many intestinal diseases and for other diseases. But its low absorption, its high dosages caused side effects on gastro-intestinal track, [...]

Evaluation of the paromomycin loading characteristics in nanoprecipitated PLGA nanospheres

Kalimouttou S., Lahiani-Skiba M., Naouli N., LIN V.S., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

The aim of this work was to optimize the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paromomycin by a nanoprecipitation technique. PLGA was choosen because of its biodegradability and biocompatibility features. In order to [...]

Influence of water-soluble polymers and surfactants, on mebendazole solubilization by _- and permethyl-_-cyclodextrins

Ba O-M., Lahiani-Skiba M., Joudieh S., Bounoure F., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

The objective of this work was to determine the influence of pH, water-soluble polymers and surfactants on mebendazole solubilization by beta- and permethyl-beta-cyclodextrins (beta-CD and PM-beta-CD). Mebendazole is an antihelmintic active drug used against a [...]