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HomeAffiliationsMcGill University

Affiliations: McGill University

Enhanced Cytotoxicity of Doxorubicin Conjugated to Ultrasmall Au Nanoparticles

Zhang E., Ntumba K., Nadeau J., McGill University, CA
In this study we find that ultra-small (mean diameter, 2.8 nm) Au nanoparticles conjugated to doxorubicin (Au-Dox) are up to five-fold more cytotoxic to B16 melanoma cells than Dox alone. The particles enter the cell [...]

A capillary effect based microfluidic system for high throughput screening of yeast cells

Mirzaei M., Juncker D., McGill University, CA
Microfluidic systems have been developed and used for high throughput cell-based assays successfully. However, these systems require complicated peripherals and a computer to control the flow, which limits their adoption by biologists. Here, we propose [...]

Light Induced Self-Inscription (LISI) in Organo-silica Network Glasses and Nanocomposite Polymers

Andrews M.P., Belanger N., Manseau M.-P., Duxin N., Maron E., Lofgreen J., van Veggel F.C.J.M., McGill University, CA
This talk focuses on two classes of nanocomposite media that exhibit Light Induced Self Inscription. We describe LISI in sol-gel derived photosensitive glasses containing nanodispersions of zirconia, titania and noble metal nanoparticles. Waveguiding at 488 [...]

Patterning Wrinkle Architectures in Nanocomposite Glasses with Self-Inscribing Guided Waves

Andrews M.P., Belanger N., McGill University, CA
We have been exploring ways in which light induced self inscribed (LISI) waveguides can impose constraints on wrinkle patterns when nanocomposite hybrid sol-gel glass films become unstable to perturbations of a certain wavelength, which reflects [...]

Visualization of quantum dot-electron donor conjugate uptake and processing by living cells

Clarke S.J., Hollmann C.A., Nadeau J.L., McGill University, CA
The interactions of semiconductor quantum dots (QDs) with living cells remain poorly understood. It is known that certain sizes (colors) of QDs penetrate more readily into subcellular compartments, such as the nucleus, or into bacteria. [...]

Surface modification and characterization of a cyclic olefin copolymer for magnetic bead-based stop-flow microfluidic ELISA

Herrmann M., Veres T., Tabrizian M., McGill University, CA
This abstract describes a microfluidic platform for simple, highly effective and parallel Enzyme Linked Immuno-Sorbent Assay (ELISA). The method is based on the use of magnetic micro-beads in order to increase the capture rate of [...]

Characterization of a Novel Self-Association of an Alternating Copolymer into Nanotubes in Solution

Malardier-Jugroot C., van de Ven T.G.M., Whitehead M.A., McGill University, CA
The characterisation of the association of an alternating copolymer was performed using theoretical methods (quantum mechanics and molecular mechanics) and experimental methods (cryo-Transmission Electron Microscopy, Neutron Reflectivity and Neutron Scattering). The most stable conformation obtained [...]

Kinetics of Microdomain Structures in Multi-Phase Polymer-Liquid Crystalline Materials

Das S.K., Rey A.D., McGill University, CA
A mesoscopic kinetic model for phase separation in the presence of liquid crystalline order has been formulated, and solved using high performance numerical methods. The thermodynamic phase diagram on temperature-polymer concentration plane indicates the presence [...]

Simulation of Carbonaceous Mesophases Micro-Textures

de Andrade Lima L.R.P., Rey A.D., McGill University, CA
Carbonaceous mesophases are liquid crystalline precursor that can be spun into carbon fibers using the melt spinning process; the manufacture optimization requires a better understanding of the principles that control the carbon fiber structure development [...]

Multiscale Simulation of Flow-Induced Texture Formation in Thermotropic Liquid Crystals

Grecov D., Rey A.D., McGill University, CA
This paper presents theory and simulation of flow-induced structures, useful to the creation of synthetic material structures and to the biomimetics of natural fibers. We present a multiscale theory and simulation of hydrodynamic texture formation [...]

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