CFD Research Corporation – Page 2

Computational Proof-of-Concept of Next-Generation Nucleotide–Tunneling-Current-Based Nanopore Sequencing Devices

Sengupta D., Jenkins J., Sikorski Z., Sundaram S., CFD Research Corporation, US

A complete knowledge of the DNA sequence of an individual can yield fundamental insight into disease diagnosis, treatment and possibly prevention. To date the most reliable method of determining a genetic sequence is through the [...]

Modeling of multi-scale processes during plasma-assisted growth of carbon nanotubes

Vasenkov A.V., Kolobov V.I., CFD Research Corporation, US

Multi-Scale Computational Framework (MSCF) has been recently developed for nanostructured materials’ fabrication. This framework integrates a Computational Fluid Dynamic solver for computing reactor scale process, a Kinetic Monte Carlo simulator for the growth of nanostructured [...]

Multi-scale, Mechano-biological Model of Nanoparticle Toxicity

Jenkins J., Pant K., Hood J., Sundaram S., CFD Research Corporation, US

Multiscale simulation of the toxic physiological effects of short and long term exposure to nanoparticles (NP) requires a unified quantitative understanding of NP deposition, partitioning of NP within the body (lung, liver, spleen, and brain), [...]

Multi-Scale Computational Framework: Theoretical approach and application for the growth of carbon nanotubes

Vasenkov A.V., Fedoseyev A.I., Kolobov V.I., Hong Ki-Ha, Choi H.S., Kim J., Kim K.H., Kim J., Kim K.H., Lee H.S., Shin J-K, CFD Research Corporation, US

The current rapid development of nanotechnology has created a significant interest to predict the behavior of materials from the atomic to the engineering scales. However, it was found that such prediction is a very challenging [...]

A Computational Model for the Design of ElectroWetting On Dielectric (EWOD) Systems

Bedekar A.S., Jenkins J.W., Sundaram S., CFD Research Corporation, US

Microfluidics has enabled the development of integrated lab-on-a-chip (LoC) devices for use in a clinical diagnostics, high throughput screening, drug discovery, biodefense and environmental monitoring. Although most microfluidic devices are based on continuous flow of [...]

Characterization of a Solid State DNA Nanopore Sequencer using Multi-Scale (Nano-to-Device) Modeling

Jenkins J.W., Sengupta D., Sundaram S., CFD Research Corporation, US

The rapid convergence of nanotechnology and biotechnology has generated a need for design tools that can incorporate sufficiently detailed models of the nanoscale molecular phenomena with overarching transport and related effects in microfluidic devices. Currently, [...]

A Multi-scale, Integrative Model of Cellular Electrophysiological Response Incorporating Intra/Extra-cellular Transport & Dynamics

Feng J.J., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

Spurred by the growing confluence of nano and bio technologies, several novel micro/nano platforms (see for example, whole cell patch clamp devices [1]) are emerging for the high-throughput and/or high-fidelity study of the electrophysiological response [...]

Multiscale (Nano-to-Micro) Design of Integrated Nanobio Systems

Jenkins J., Hagan M., Chakraborty A., Sundaram S., CFD Research Corporation, US

Biological systems have the first level of organization at the nanoscale. Proteins, DNA, RNA, ion channels are nanoscale systems that leverage molecular interactions to perform specific tasks. Integrated nano-bio systems have emerged as strong candidates [...]

Numerical and Analytical Studies of Electrothermally Induced Flow And Its Application For Mixing and Cleaning in Microfluidic Systems

Feng J.J., Krishnamoorthy S., Sandaram S., CFD Research Corporation, US

This paper presents both analytic and simulation results of electrothermal flow in microfluidic systems. It also considers the application of this phenomenon to microscale mixing and cleaning. The basic operation requires application of an alternating [...]

Analysis of Blood Extraction from a Lancet Puncture

Kuriger R.J., Romanowicz B.F., CFD Research Corporation, US

A computational model was created utilizing the CFD-ACE+ software to model blood flow from a lancet puncture of the skin. A two-dimensional axisymmetric model was developed and the skin tissue was modeled as a porous [...]