US – Page 69 – TechConnect Briefs

A Simple Method for Fabrication of Microarrays and Microfluidic Device Using PDMS Stamp

Lee H., Koh D., Oh K.W., SUNY at Buffalo, US

We describe a simple micro-fabrication method by using polydimethylsiloxane (PDMS) stamp on a glass substrate. While the microwells used previously facilitated the cell-to-cell formation by PDMS stamping method, not only should it be carefully controlled [...]

Nephrotoxicity of Dextran Functionalized Graphene Nanoparticles and Their Potential as Magnetic Imaging Contrast Agents for Renal Abnormalities

Lee S., Kanakia S., Toussaint J., Kukarni P., Chowdhury S.M., Khan S., Shroyer K., Moore W., Sitharaman B., Stony Brook University, US

Contrast-enhanced magnetic resonance angiography (MRA) employs the use of blood pool contrast agents (CA) such as gadolinium (Gd3+) complexes that allow for delayed phase arterial and venous imaging and improve the sensitivity in detecting small [...]

In Situ Health Monitoring of Piezoelectric Sensors

Jensen S.L., NASA - Stennis Space Center, US

The technology developed is an in-situ measurement system for monitoring the performance of piezoelectronic sensors, particularly accelerometers. With this technology, characteristics such as resonant frequency, response, cable status, connectivity, bonding and linear range, can be [...]

A Nanobiomimetic Neuronal Memcapacitor Serves as a Voltage Sensor and an Amperometry Sensor for Reagent-less Direct Detection of Sub pM Soluble Amyloid-beta

Duh S-H, Thornton J., Kissinger P.T., Chen E.T., Advanced Biomimetic Sensors, Inc., US

Amyloid-beta (A) plaque accumulation in the brain has been recognized to be associated with Alzheimer’s and dementia. Challenges of quantitation of Ab are the instability of soluble Ab1-42 and the protein interference plus the time [...]

Enhanced Kinetics of Enzymatic Nanosensors

Breger J., Walper S., Ancona M., Stewart M., Susumu K., Medintz I., Naval Research Laboratory, US

Nanosensors employing quantum dots (QDs) and functional moieties such as enzymes are promising for diagnostics and chemical/biological threat activity. Their small size permits cell penetration and their inherent photochemical properties are well-suited for rapid, optical [...]

Beyond Biomarkers: Array-Based Profiling for Diagnostics and High-Throughput Screening

Rotello V., University of Massachusetts Amherst, US

The "chemical nose/tongue" approach presents a potential alternative to specific recognition and separations techniques. In this approach a sensor array is generated to provide differential interaction with analytes via selective receptors, generating a stimulus response [...]

Cyanide Detection by Highly Modified Sol-Gel Biocomposite Sensor

Mozneb S., Lai J.C.K., Leung S.W., Idaho State University, US

Cyanide is an important industrial chemical but is also very toxic. Cyanide binds strongly with hemoglobin than that of oxygen which causes histoxic hypoxia, if cyanide is ingested into the bloodstream. This pairing reaction can [...]

Environmental Health Science and SBIR/STTR Small Business Grants

Shaughnessy D., Henry H., Ahlmark K., Mease K., Balshaw D., NIH, US

The NIEHS sets aside a percentage of extramural funds to support technology development for environmental health research through Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants. SBIR/STTR technologies supported by NIEHS [...]

Comprehensive Analysis of High Performing Electrochemical Biosensors and Their Applications

Assan D., Lai J.C.K., Leung S.W., Idaho State University, US

We have mounted 5 different biocatalysts on a sensor platform to examine the performance of this electrochemical sensing system for the detection of different biomolecules/metabolites and environmental important molecules, with such we also compared how [...]

Cellular Delivery Modalities for Semiconductor Quantum Dots: A Comparative Analysis

Field L.D., Naval Research Lab/ University of Maryland College Park, US

Fluorescence continues to be one of the most useful tools employed by life scientists to visualize cellular processes. Semiconductor nanocrystals or quantum dots (QDs) have been demonstrated to be superior alternatives to traditional fluorophores (dyes [...]