US – Page 383 – TechConnect Briefs

Combinatorial Selection of Cell-Specific Peptides by Phage Display Experiments

Veleva A.N., Patterson C., Cooper S.L., North Carolina State University, US

We report for the first time the selection of novel peptides that are highly specific for endothelial progenitor cells (EPC) by screening phage display libraries. Our strategy for isolation of ligand peptides for cell surface [...]

Smart Bandage – A Hydrogel Supported Optical Microcavity Sensor

DeLouise L.A., University of Rochester, US

Developing new medical diagnostic technologies that can be used in the home for early detection and disease prevention is a central focus at the University of Rochester Center for Future Health. This paper is concerned [...]

Electronic Sensing of Antibodies using Carbon Nanotube Devices

Teker K., Sivakumar K., Wickstrom E., Panchapakesan B., University of Delaware, US

Carbon nanotubes (CNTs) are remarkable solid state nanomaterials due to their unique properties such as high surface area, hollow cavities, and excellent mechanical and electrical properties. Interfacing carbon nanotubes with biological materials could enable significant [...]

Optimal Design of Laser Surgery for Cancer Treatment Through Nanoshell-Mediated Hyperthermia Therapy

Feng Y., Rylander N., Bass J., Oden J.T., Diller K., The University of Texas at Austin, US

Recent development of nanoparticle technology and its application in hyperthermia therapies makes it possible to consider optimal control of the temperature field and thermal energy delivered to the tumor region with minimal destruction of surrounding [...]

Photo-Enhanced Luminescence in Bio-conjugated Quantum Dots for Ovarian Cancer Biomarkers

Dybiec M., Korsunska N.E., Zhukov P., Zhukov T., Ostapenko S., Sellers T., Zajac A., Zhukov P., Zhukov T., University of South Florida, US

Ovarian cancer is the most lethal gynecologic malignancy. This largely reflects the fact that approximately 75% of cases are detected at advanced stages of disease, when cure is unlikely. In contrast, 5-year survival for patients [...]

Effect of High AC Magnetic Field on Magnetic Nanoparticles for Magnetic Hyperthermia and Radiation/Chemotherapy Applications

Belc D., Chen C., Roberts R., Bettge M., Arora R., Mohite V., Florida State University, US

There are numerous studies in the field that explain and model the behavior and heating properties of magnetic nanoparticles (NPs) when exposed to an alternating magnetic field [1, 2]. Particularly for applications such as magnetic [...]

(Salen)Mn(III) Compound as a Nonpeptidyl Mimic of Catalase: Theoretical Study of the Reaction Mechanism and Comparison with (Salen)Mn Catalyzed Epoxidation Activities

Abashkin Y.G., Burt S.K., National Cancer Institute, US

Catalase mimics can be used as therapeutic agents against oxidative stress in treatment of many diseases including Alzheimer’s disease, stroke, heart disease, aging and cancer. (Salen)Mn(III) compounds have been proven to be promising as synthetic [...]

Chemotaxis of Metastatic Breast Cancer Cells in Parallel Gradient Microfluidic Chambers

Saadi W., Wang S-J, Lin F., Jeon N.L., University of California Irvine, US

Chemotaxis plays a key role in cancer metastasis, directing the motility of metastatic cells through gradients of growth factors or other chemoattractants. In order to rigorously characterize the role of growth factors in cancer cell [...]

Colloidal Gold Nanoparticles: A Versatile Platform for Developing Tumor Targeted Cancer Therapies

Paciotti G.F., Myer L., Kingston D.G.I., Ganesh T., Tamarkin L., CytImmune Sciences, Inc, US

CytImmune Sciences is developing colloidal gold nanoparticles (cAu) as a platform for tumor targeted drug delivery. Specifically two drugs are discussed: Aurimune-T and AuriTax. Aurimune-T is manufactured by covalently linking molecules of TNF and Thiol-derivatized [...]

The Use of Ligand Conjugated Superparamagnetic Iron Oxide Nanoparticles (SPION) for Early Detection of Metastases

Leuschner C., Kumar C., Urbina M.O., Zhou J., Soboyejo W., Hansel W., Hormes F., Pennington Biomedical Research Center, US

Breast cancer is the most common cause of cancer death in women; more than 75 % of patients die from skeletal metastases. The accurate diagnosis of metastatic disease is therefore crucial for treatment and survival. [...]