US – Page 37 – TechConnect Briefs

Modular Nanoparticle Probes for Personalized in Vitro and in Vivo Imaging of Cancer Cell Populations

Nallathamby P.D., Cowden-Dahl K., Roeder R.K., University of Notre Dame, US

The high mortality and poor prognosis for women diagnosed with ovarian cancer is mainly due to late diagnosis. Improved detection of primary tumors and recurrence after chemotherapy is, therefore, crucial to reduce ovarian cancer mortality [...]

Point-of-Care (POC) Micro Biochip for Cancer Diagnostics

Nunna B.B., Lee E-S, New Jersey Institute of Technology, US

American cancer society stated that a total of 1,685,210 new cancer diagnosed cases out of which 595,690 deaths from cancer are expected to be reported in the United States of America in 2016. Unfortunately Cancer [...]

Positively charged Ag-dendron conjugates: Stability enhanced AgNPs for biomedical applications

Cho T.J., Liu J., Hackley V.A., National Institute of Standards and Technology, US

We developed positively charged silver nanoparticles ([Ag-Ds]+), nominally 20 nm in diameter, using dendron chemistry combined with reduction of silver nitrate in the presence of sodium borohydride. The conjugate was developed within the context of [...]

Application of a Next Generation Hand Held Antimicrobial Cold Plasma Technology

Kim H., Izadjoo M., Izadjoo S., Marcel V., Truong H., Izadjoo M., Izadjoo S., Trideum Biociences and ChiScan LLC, US

Due to emergence of antibiotic and multi-drug resistant infectious agents, there is a growing need for development of novel and effective antimicrobial therapeutics and devices. Innovative anti-infective treatment modalities, particularly for multi-drug resistant infections and [...]

miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application

Montgomery A., Bawage S., Chaudhary A., Singh S.R., Vig K., Alabama State University, US

Gold Nanoparticles are popular because of their use in drug delivery and other biomedical applications. However, not much is known about their toxicity. The purpose of the present study was to evaluate the toxicity of [...]

DEVELOPMENT OF SUSTAIN RELEASE POVIDONE IODINE OPHTHALMIC DROP THROUGH NOVEL IN-SITU GEL FORMULATION

Wei G., Gao X., Li X., Liang B., Lu Y., Baldwin J.J., Liang B., IVIEW Therapeutics Inc., US

Acute conjunctivitis (“pink eye”) is one of the most common and most contagious ocular infections seen in the United States, Japan and Europe. There are 5.9 million cases of infectious conjunctivitis annually in the United [...]

Novel Nano-biomaterials for Inhibition of Respiratory Syncytial Virus

Joshi S., Kirby D., Perrie Y., Singh S.R., Alabama State University, US

The liposomes were prepared using the conventional thin film hydration method with and without peptide RF-482. The loading of RF-482 was determined using BCA assay and the RSV inhibition was studied using immune-fluorescence imaging, plaque [...]

Magnetically Targeted Endothelial Cells for Prevention of Vascular Restenosis

Polyak B., Drexel University, US

The advent of percutaneous transluminal angioplasty with stent implantation and the even more recent use of drug-eluting stents have resulted in a paradigm shift in the care of obstructive vascular disease. However, deleterious sequelae of [...]

Nano-magnetically targeted drug delivery system for treating Atrial Fibrillation (AF)

Harel A., NanoMed Targeting Systems Inc., US

NanoMed Targeting Systems (NTS) is developing magnetically targeted drug delivery systems for treating atrial fibrillation. This platform system is based on proprietary superparamagnetic nanoparticles attached to the payload, and its non-invasive proprietary magnetic guiding system. [...]

Platform Reagent Development for the Intracellular Delivery of Therapeutic Peptides

Evans B.C., Lander C., Duvall C.L., Moerae Matrix, Inc., US

Peptides hold many advantages over the small molecule drugs that dominate the current healthcare market in terms of potency, specificity, and biocompatibility, and they are faster and easier to implement than genetic modifications for completion [...]