US – Page 311 – TechConnect Briefs

A Targeted Nanotechnology-based Therapeutic System for the Combined Chemoprevention of Colon Cancer

Prabhu S., Kanthamneni N., College of Pharmacy, Western University of Health Sciences, US

Colorectal cancer (CRC) is the second most common cause of cancer death in the USA. Current research is shifting the focus from chemotherapy to chemoprevention. The overall goal was to develop a low dose, novel [...]

Targeted Nanoparticle-Polypeptide Conjugates for Breast Cancer Treatment

Alexis F., Basto P., Radovic-Moreno A., Langer R., Farokhzad O.C., Brigham and Women's Hospital, Harvard Medical School, US

We have developed a polymeric targeted nanoparticle-polypeptide conjugates that shows cell binding speficity and stealth properties. The targeted naoparticles binds and are taken up efficiently by Her2 expressing breast cancer cells. These nanoparticles represent a [...]

Delivery of Shiga Toxin 1 A Subunit into Epithelial Cells Using Silica-Based Nanowires

Kwon N.H., Beaux M., Sheng H., Ebert C., Wang L., McIlroy D.N., Hovde C.J., Bohach G.A., University of Idaho, US

Silica-based nanowires were used to introduce the Shiga toxin 1 A subunit (StxA1) into bovine and human epithelial cells. We extended our previous technology which employs fibronectin (Fn) as a ligand to induce integrin-mediated uptake [...]

Differential Uptake of PEG-Silica-FITC Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells

Iwakuma N., Sharma P., Delano M.J., Moldawer L.L., Moudgil B.M., Grobmyer S.R., University of Florida, US

Background: An understanding of uptake of nanoparticles (NPs) by human cancer cells and non-cancer cells is important for the development of NPs as novel cancer therapeutic and diagnostic agents. Hypothesis: Uptake of NPs is increased [...]

An Investigation of Cellular Toxicity of Carbon Nanomaterials in African American Breast Cancer Cells

Taylor T., Dean D., Troy R., Leggett-Robinson P.M., Tuskegee University, US

Functionalized CNTs and CNFs are attractive not only because they are theoretically easier to disperse in organic solvents and water, but also because there is some evidence that these modifications may enhance solubility and/or decrease [...]

Nanoprobe for Optical Molecular Imaging

Zheng S., Wang R., Che W., Harrison W.J., Yang Z., Li C., Eastman Kodak Company, US

Optical molecular imaging (OMI) is a very powerful tool for studying the temporal and spatial dynamics of specific biomolecules and their interactions in real time in vivo. It exhibits the great advantages of high temporal [...]

Chemical imaging using molecular spectroscopy – providing answers to fundamental biomedical questions at the nanoscale

Whitley A., Gilmore A., Tay L., Lee E., Adar F., HORIBA Jobin Yvon, US

HORIBA Jobin Yvon have been at the cutting edge of major breakthroughs in many key areas of instrument development and materials analysis including the latest hybrid approach of combining two or more techniques in one [...]

Characterization of Nano- & Microparticles Suitable for Drug & Gene Delivery by Freeze-fracture Electron Microscopy

Papahadjopoulos-Sternberg B., NanoAnalytical Laboratory, US

The potency of drug/gene-loaded nanoparticles is frequently depending upon their morphology adopted in a biological relevant environment. Freeze-fracture electron microscopy (ff-em) is a powerful techniques to monitor the self-assembling of lipid-, polymer-, as well as [...]

Targeting Nanoparticles to Tumors using Adenoviral Vectors

Saini V., Enervold M.R., Perez A., Koploy A., Perkins G., Ellisman M.H., Green H.N., Mirov S.B., Zharov V.P., Everts M., University of Alabama at Birmingham, US

Despite advances in detection and treatment of cancer, development of novel therapies remains essential; in this regard, nanotechnology holds great promise. For example, tumor imaging opportunities have expanded by the development of quantum dots (QDs) [...]

Heating efficiency of debundled carbon nanotubes compared to carbon black

Levi N.H., Carroll D.L., Wake Forest University, US

This work examines the amount of heat generated by single-wall and multi-wall carbon nanotubes to show how bundling and adequate dispersion of the tubes effects heat generation. Due to their high aspect ratio, nanotubes behave [...]