US – Page 309 – TechConnect Briefs

Electronic DNA detection on semiconductor surfaces

Han Y., Tan E., Candebat D., Bandyopadhyay K., Niemz A., Keck Graduation Institute, US

Electronic biosensors offer a viable alternative to optical biosensors for the rapid, specific, and sensitive detection of DNA. We are utilizing an electrolyte-oxide-semiconductor (EOS) biosensor system on a SiO2/Si surface for impedimetric detection of DNA. [...]

Synthesis of a nano electro-magnetic polymer and its application in a DCT biosensor

Pal S., Hummel E.B., Alocilja E.C., Michigan State University, US

This experimental study was focused on the development of a nanomagnetic conductive polymer and its application in a direct-charge transfer biosensor (Figure1) for the detection of Bacillus species. A polyaniline-γFe2O3 nanocomposite transducer was first synthesized [...]

Nanoelectrodes with Selective Molecular Receptors for Label-Free Electronic Detection of Thrombin

Dong J., Parviz B.A., University of Washington, US

The enzyme thrombin plays a crucial role in the regulation of blood coagulation. We present a sensor that can directly detect this enzyme and generate an electronic signal. The sensor structure consists of three electrodes [...]

Fabrication and Characterization of Nano-Field Effect Transistor for Bio-safety

Mishra N., Winterrowd P., Nelson R., Rastogi S., Maki G., Maki W., Maki G., Maki W., University of Idaho, US

The sensitive and robust detection of harmful biological and chemical molecules in the various samples have incredible significance in modern healthcare. New research in the field of nanowires has evidence that nanowire based diagnostic methods [...]

Homogeneous Bioluminescence Resonant Energy Transfer On High Density Array Imaging Chip

Filanoski B., Rastogi S., Cameron E., Mishra N., Maki W., University of Idaho, US

Fluorescent microarray technologies are widely used in molecular biology for studying gene expression, immune detection and drug discovery. Fluorescent assays are very sensitive but present problems with many bio-agents having inherent fluorescence which interfere with [...]

SERS Nanotags for Point-of-Care Diagnostics

Natan M., Oxonica, US

A holy grail in point-of-care diagnostics is to develop tests that perform on par with the central laboratory in terms of robustness, multi-analyte capability, precision, and sensitivity. Oxonica has developed a series of proprietary, nanoscale [...]

Nanoplex(TM) Biotags: Near-IR Excited, Highly Multiplexed Nanoparticulate Optical Detection Tags for Diagnostic Assays

Penn S., Cromer R., Sha M., Doering B., Brown B., Norton S., Walton I., Oxonica Inc, US

Oxonica Inc has developed a novel optical detection tag for use in point of care diagnostics, cellular imaging assays, and life science assays. Nanoplex(TM) Biotags are silica coated Au nanoparticles that, by virtue of surface [...]

Peptide Nucleic Acids Modified Nano-Biosensor for Early Cancer Diagnosis

Rastogi S., Mishra N., Winterrowd P., Nelson R., Maki W., University of Idaho, US

Epigenetics is proving to have an increasingly important role in both human development and disease, particularly cancer. DNA methylation is one of two epigenetic alterations. A distinct set of tumor types has a high level [...]

Rapid Isothermal Amplification and Multiplexed Surface Detection of Short DNA Sequences

Tan E., Han Y., Kniazeva E., Buechel M., Erwin B., Niemz A., Keck Graduate Institute, US

We have coupled a novel isothermal amplification method for short oligonucleotides (EXPAR) with solution and surface-based detection involving DNA-functionalized gold nanospheres. In these assays, a trigger oligonucleotide is exponentially amplified and converted to a reporter [...]

Development of a Magnetically Triggered Drug Delivery System using Thermoresponsive Grafted Polymer Networks with Magnetic Nanoparticles

Ankareddi I., Hampel M.L., Sewell M.K., Kim D-H., The University of Alabama, US

A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event (Brazel et al., 2006) was developed. The desirable carrier [...]