US – Page 171 – TechConnect Briefs

Molecular Effects of Silicon Dioxide Nanoparticles on Cell Survival Signaling of Dorsal Root Ganglion (DRG) Neurons and Schwann Cells

Jain A., Jaiswal A.R., Lu S., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

The molecular mechanisms underlying the pathophysiology of peripheral neuropathies have not been fully elucidated. To meet the need for suitable cell culture models in vitro of peripheral nervous system (PNS) neural cells that allow long-term [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]

Differential Cytotoxic Effects of Titanium Oxide Nanoparticles on Peripheral Nervous System Neural Cells

Lu S., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University College of Pharmacy, US

The health impact of exposure to TiO2 nanoparticles is poorly documented although exposure to the particles is known to elicit inflammatory responses in lung tissue. We recently found treatment with TiO2 micro- or nanoparticles induce [...]

California’s Approach for safe Nanotechnologies: Second Information Call-in from Manufacturers

Kang H.Y., Takatori S., Cal/EPA, US

The California Environmental Protection Agency’s Department of Toxic Substances Control (DTSC) initiated the second chemical information call-in on nanometal oxides (titanium dioxide, cerium oxide, and zinc oxide), nanometals (silver and zero valent iron), and quantum [...]

A novel technique for toxicological characterization of engineered nanomaterials

Demokritou P., Sotiriou G.A., Diaz E., Godleski J., Brain J., Pratsinis S.E., Harvard University, US

How do we balance the potential hazards from new and inadequately characterized engineered nanomaterials with the potential and power of nanotechnology? It has become apparent, that potential environmental health effects are critical factors in the [...]

The Development of a Portable Arsenic Detector Based on Surface-Enhanced Raman Spectroscopy for Rapid on-Site Testing of Groundwater

Wang K.Q., Wang Y., Pan G., Wang K.Q., Wang Y., Agiltron, Inc., US

The combination of high toxicity and widespread occurrence has created a pressing need for effective monitoring of arsenic in groundwater. Although laboratory analysis has been used to measure arsenic in collected groundwater samples, the time [...]

Effect of Carbon Nanotubes on Chinese Hamster Ovarian Cells

Chen H.H., Chen M., Luca J.A., Chen H.H., Chen M., Point Loma Nazarene University, US

We report the effect of carbon nanotubes at the cellular level using purified single-walled carbon nanotubes (SWNTs) resuspended in physiological compatible phosphate buffered saline (PBS) and systematically study its impact on Chinese Hamster Ovarian (CHO) [...]

Nanoparticle Release from Polymer Nanocomposites Used for Potable Water Infrastructure and Food Packaging: Current Progress & Beyond

Whelton A.J., Duncan T.V., Koontz J.L., Nguyen T., University of South Alabama, US

Engineered nanoparticles (ENP) are increasingly being integrated into polymeric infrastructure and food packaging materials worldwide. ENPs can improve product strength, extend infrastructure service life, and increase a polymer’s antimicrobial resistance and oxygen barrier properties. While [...]

Genomic Mappings and Frequency Domain Analysis

Lyshevski S.E., Rochester Institute of Technology, US

We study the feasibility of analysis and the evaluation of large-scale genomic and proteomic data by applying frequency concepts. The frequency-domain estimates and measures lead to the informative analysis departing from statistical methods. The frequency [...]

Novel alternative, multistranded, plasmid, and helical transitional DNA and RNA microarrays: the next generation of nucleic acid microarrays

Gagna C.E., Lambert W.C., New York Institute of Technology, US

Novel multistranded and alternative DNA, RNA and plasmid microarrays have been developed that allow for immobilization of intact, nondenatured nucleic acids. Biomolecules are anchored onto a solid support and can move freely, while researchers experiment [...]