IT – Page 5 – TechConnect Briefs

Development of Innovative Packaging Characterized by Active Thermal Insulation Properties

Garbagnoli P., Altomare L., Del Curto B., De Nardo L., Del Curto B., Cigada A., Politecnico di Milano, IT

An innovative composite material based on cellulose matrix has been developed. Active thermal insulation properties have been conferred to the material through the integration of Phase Change Materials (PCM) into the matrix. Processing techniques of [...]

Intelligent testing strategy for engineered nanomaterials

Pozzi-Mucelli S., Balharry D., Stone V., Veneto Nanotech SCpA, IT

The exciting properties exhibited by nanomaterials have led to the development of vast numbers of different types of nanomaterials for a variety of applications. Such applications include medicines, cosmetics, clothing, food, food packaging, sporting equipment, [...]

‘Sink effect’ of dually-decorated nanoliposomes on Abeta clearance

Re F., Minniti S., Bana L., Masserini M., Re F., University Milano Bicocca, IT

Plaques containing beta-amyloid peptides are one of the hallmarks of Alzheimer’s disease (AD) and the reduction of Abeta is considered a primary therapeutic target. Recently, strategies have been employed to reduce Abeta brain levels and [...]

NAD-Nanoparticles for Therapy and Diagnosis of Alzheimer Disease

Masserini M., Gregori M., Salvati E., Re F., Masserini M., University Milano Bicocca, IT

NAD project (large cooperative; 19 partners, funded by the E.C.) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by synthesis of multiple-functionalized nanoparticles, able to bind, detect and remove Abeta from [...]

Effect of cholesterol on the transfection efficiency of DOTAP-containing lipoplexes

Pozzi D., Cardarelli F., Salomone F., Marchini C., Amenitsch H., Caracciolo G., Sapienza University of Rome, IT

Here, we have studied the effect of cholesterol on the transfection efficiency (TE) of cationic liposomes made of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and dioleoylphosphocholine (DOPC) in Chinese hamster ovary (CHO) cells. We held the charge of the [...]

Exploiting the “protein corona effect” for targeted drug and gene delivery

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Salomone F., Laganà A., Sapienza University of Rome, IT

When administered in vivo lipid nanoparticles (NPs) are immediately covered by a rich protein layer, known as “protein corona” that changes the size, aggregation state, and interfacial properties of the NP, giving it a biological [...]

Large-scale manufacturing of radiation sculptured therapeutic nanogels

Dispenza C., Grimaldi N., Sabatino M.-A., Adamo G., Rigogliuso S., Ghersi G., Università di Palermo, IT

Pulsed electron-beam irradiation of poly(N-vinyl pyrrolidone) (PVP) aqueous solutions, at relatively low energy per pulse and doses within the sterilization dose range, has led to a variety of PVP nanogels of controlled size, that can [...]

Water-borne Polymeric Nanoparticles for Glutathione-Mediated Intracellular Delivery of Anticancer Drugs

Grimaldi N., università degli studi di palermo, IT

A new family of water-borne, biocompatible and carboxyl-functionalized nanogels (NGs) was developed for glutathione-mediated delivery of anticancer drugs. Nanogels were generated by e-beam irradiation of aqueous solutions of a crosslinkable polymer. Molecular structure and topology [...]

In vivo nanotoxicology: Toxicoproteomics

Sabella S., Kote S., Pompa P.P., Italian Institute of Technology, IT

Proteomics applied to nanotechnology is now emerging as an attractive tool to address the still unanswered questions dealing with nano-biointeractions and NPs-induced toxicity in living systems. The unique advantage provided by “omic” techniques (such as, [...]

Development of a high sensitivity fluorescence immunoassay for Amyloid Beta 42 by a silicon microarray platform

Cretich M., Gagni P., Chiari M., Consiglio Nazionale delle Ricerche, IT

Alzheimer’s disease (AD) affects millions of people around the world with rising incidence as population age. Here we present the use of a label/label free silicon/silicon oxide (Si/SiO2) based microarray platform to develop a highly [...]