FR – Page 19 – TechConnect Briefs

Evaluation of the paromomycin loading characteristics in nanoprecipitated PLGA nanospheres

Kalimouttou S., Lahiani-Skiba M., Naouli N., LIN V.S., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

The aim of this work was to optimize the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paromomycin by a nanoprecipitation technique. PLGA was choosen because of its biodegradability and biocompatibility features. In order to [...]

Influence of water-soluble polymers and surfactants, on mebendazole solubilization by _- and permethyl-_-cyclodextrins

Ba O-M., Lahiani-Skiba M., Joudieh S., Bounoure F., Lahiani-Skiba M., Skiba M., Université de Rouen, FR

The objective of this work was to determine the influence of pH, water-soluble polymers and surfactants on mebendazole solubilization by beta- and permethyl-beta-cyclodextrins (beta-CD and PM-beta-CD). Mebendazole is an antihelmintic active drug used against a [...]

Delivery systems for enhanced siRNA delivery

Bolcato-Bellemin A-L., Bonnet M-E., Behr J-P., Erbacher P., Polyplus-transfection, FR

To fully exploit the vast potential of RNA interference, the development of safe and efficient reagent to deliver small amount of siRNA is necessary. We have explored the potential of in vivo-jetPEI™, an optimized linear [...]

Effect of Ligand Nature on the Kinetics and the Redistribution of Quantum Dots in Mice

Daou T.J., Li L., Reiss P., Texier-Nogues I., CEA-Grenoble, FR

The meeting of nano-materials with biology has produced a new generation of technologies that can profoundly impact biomedical research. The NIR emitting window (650-900 nm) is appealing for in vivo optical imaging because of the [...]

Exploring the behavior of concentrated collagen, approaches to tailor biomimetic materials

Gobeaux F., Mosser G., Anglo A., Panine P., Davidson P., Giraud-Guille M.-M., Belamie E., Ecole Pratique des Hautes Etudes, FR

Dense ordered collagen matrices can be obtained by fine tuning the electrostatic interactions in highly concentrated solutions of type I collagen. Such biomimetic fibrillar materials have a high application potential in the field of tissue [...]

Experimental evaluation of individual protection devices against nanoaerosols:

Golanski L., Rouillon F., Guiot A., Bernard S., Tardif F., CEA, FR

Analysts have estimated that the worldwide market for nanoparticles will be about 340 billion Euro in 2011 which would rank it alongside the automobile and microelectronic industries. However, potential impact of these new materials on [...]

Specific device for cells sampling

Cosnier M.L., Martin F., Ratel D., Berger F., Caillat P., Commissariat à l’Energie Atomique, FR

We developed a miniaturized biopsy tool for harvesting molecules of interest in delicate areas such as brain. This tool permits harvesting of intact cells permitting genomic analysis on these cells. The sampling tool is manufactured [...]

Mechanical characterization of electrostatic MEMS switches

Souchon F., Koszewski A., Levy D., Charvet PL., CEA/LETI/MINATEC, FR

The paper presents a methodology with nanoindentation experiments to characterize the mechanical properties of MEMS switches. After that, simple analytical models for mechanical and electrostatic aspects are used to validate these mechanical characterizations. At the [...]

Advanced fluorescent nanotracers: a broad field of application

Raccurt O., Samuel J., Poncelet O., Szenknect S., Tardif F., Laboratory of Tracers Technologies, FR

Optical and magnetic nanoparticles are both attractive fields of investigation which are gaining in importance due to their potential markets e.g. polymer nano-composite, colloidal dispersion, environmental monitoring or biomedical diagnostics, etc. Among all the spectroscopic [...]

Structure-Property Correlations in ZnO Tetrapods and Spheres prepared by Chemical Vapour Synthesis

Bacsa R., Bacsa W., Verelst M., Dexpert J., Bacsa R., Bacsa W., Serp P., CEMES CNRS Univ Toulouse, FR

ZnO is a direct band gap semiconductor that finds applications in varistors and arrestors. Efficient luminescence in the UV of high purity nanocrystalline ZnO nanoparticles (20-50nm) is used in medicine and in the cosmetic industry [...]