Micro, Nano & Bio Fluidics – TechConnect Briefs

Combined effects of pump and capillary pressures for the filling of microchannel networks: the difficulty of synchronization

Berthier J., Diakite M.L., CEA-Leti (University Grenoble Alpes), FR

In this work, we first propose a model for the filling of a capillary tube driven by a pressure pump. It is shown that the filling time depends not only on the pump pressure but [...]

Fabrication of Conductive Nanoporous Membranes using Self-Assembling Block for Electrically Controlled Diffusive Flow

Ozalp E.I., Kim S., Sundar V., Zhu J.-G., Weldon J.A., Carnegie Mellon University, US

Nanoporous membranes have been recognized as promising candidates for drug delivery applications due to their small pore size and high surface-to-volume ratio1. The ultimate goal of smart drug delivery systems is to release a specific [...]

Microfluidic platform for studies of self-organizing processes in a bacterial cell

Yang D., Jennings A., Männik J., University of Tennessee, US

Cells maintain their structure and reproduce through numerous self-organizing processes. The common approach to understand how cellular organization is maintained is to perturb this organization and then observe a response from the cell. Essentially all [...]

Field-directed Self-assembly of Multifunctional Magnetic-Plasmonic Core-shell Nanoparticles with Applications to Photonics

Xue X., Liu K., Wang J., Furlani E.P., University at Buffalo (SUNY), US

Interest in the manipulation and self-assembly of magnetic nanoparticles has grown in recent years due to advances in particle synthesis and functionalization, which have led to a proliferation of applications that include the biomolecular transport, [...]

Evaporation of Binary Mixture Nanofluid Drops: Pattern Formation

Parsa M., Harmand S., Sefiane K., Bigerelle M., University of Valenciennes, FR

After the complete evaporation of a sessile nanofluid drop, different deposition patterns can be formed on a substrate. The study of deposited patterns left after the drying of a drop containing suspensions has a significant [...]

Droplet formation of highly viscous Newtonian and non-Newtonian fluids in a microfluidic flow focusing device: scaling of droplet size and production frequency

Authesserre C., Bottausci F., Costa G., Alessio M., Benhamou P-Y., Icard B., Rivera F., CEA-Leti Grenoble, FR

Polymer particles are largely used for different applications such as chromatography columns, calibration standards, drug delivery or cell encapsulation1. For all these applications, high size monodispersity and production frequency are required. Moreover, the polymers are [...]

Drying Graphene Nanofluid on Heated Substrate

Chen P., University of Valenciennes, FR

With many extraordinary properties, especially the extremely high thermal conductivity, the graphene has potential applications in energy, electronic, medicine and so on. The addition of graphene nanoparticle to prepare water-based or ethylene-glycol-based nanofluid can significantly [...]

Natural Convection of a Nanofluid in a Conical Container

Mahfoud B., Bendjaghlouli A., Bessaïh R., University of Bouira Algeria, DZ

Natural convection is simulated in a truncated cone filled with nanofluid. Inclined walls wall have constant temperature where the heat source is located on the bottom wall of the conical container which is thermally insulated. [...]

Study on Sodium Nanofluid for Fast Reactor (1)Concept of Sodium Nanofluid

Saito J.-I., Nagai K., Ara K., Japan Atomic Energy Agency, JP

Liquid sodium is used for a coolant of fast reactor (FR), because it has superior properties. For example, there are high heat conductivity, high melting temperature and excellent compatibility with structural materials. However high reactivity [...]

Study on Sodium Nanofluid for Fast Reactor (2)Reaction Suppression of Sodium Nanofluid

Nagai K., Saito J., Ara K., Japan Atomic Energy Agency, JP

　　Liquid sodium is used for a coolant of fast reactor, because of its superior thermal properties and high melting temperature etc. However liquid sodium has high chemical reactivity with oxygen or water. This is the [...]

Capillary flow of whole blood in microsystems: non-Newtonian blood behavior and substrate reagent-coating effect

Berthier J., Gosselin D., Huet M., Sabatte G., Cosnier M.L., Pouteau P., Cubizolles M., CEA-Leti (University Grenoble Alpes), FR

Introduction: The use of whole blood is a preferred solution for portable diagnostic and monitoring systems. We analyze here two particularities of microsystems for blood analysis: the blood non-Newtonian behavior, and the capillary flow in [...]

nano Droplet Array Plates (nDAPs): 3D Cell Culture in Anchored Hydrogel Droplets Compatible with Conventional Microplates

Xu Q.F., Chen X., Lyons A.M., ARL Designs LLC, US

University researchers as well as large pharmaceutical companies need improved technologies for discovering new drugs. Current drug-discovery approaches are highly inefficient, as

Reviving natural product and drug discovery pipelines with fungal artificial chromosome (FAC) technology

Clevenger K., Bok J.W., Ye R., Miley G., Velk T., Chen C., Yang K.H., Gao P., Lamprecht M., Thomas P., Islam M.D., Keller N., Kelleher N., Wu C., Intact Genomics, Inc., US

We have developed the fungal artificial chromosome [FAC, or autonomously replicating E. coli- fungal shuttle bacterial artificial chromosome (BAC)] vector and system. The FAC technology enables unbiased capturing of 263 full-length large secondary metabolite (SM) [...]

Open Droplets: Programming Chemical Flow in Microfluidics

Baret J-C., University of Bordeaux, FR

Droplet-based microfluidics is the key technology for the miniaturization and automation of assays in microcompartments. It relies on the use of emulsion droplets as microreactors each encapsulating a biological system of interest (genes, cells, drugs,...) [...]

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