Papers – Page 23 – TechConnect Briefs

Plasmonic Nanobubbles as Tunable Theranostic Agents

Lukianova-Hleb E., Constantinou P., Danysh D.S. Wagner B., Drezek R.A., Hafner J.H., Farach-Carson M.C., Carson D.D., Farach-Carson M.C., Lapotko D.O., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids

Chernenko T., Shah R., Zuser E., Diem M., Amiji M., Northeastern University, US

Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which [...]

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]

Nanoencapsulated Drug-Carrying System for Photodynamic Antimicrobial Chemotherapy (PACT)

Kalapala G.K.M., Fu P.K.-L., Governors State University, US

Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States,the expense of treating [...]

Concentration and characterization of influenza antigen bulks for potential novel vaccine delivery applications

Scampini A., Gallorini S., Baudner B.C., Palladino G., Singh M., O’Hagan D.T., Kommareddy S., Novartis, US

As a part of reformulating influenza vaccines by novel delivery technologies it is essential to work with concentrated antigens. The purpose of this study was to concentrate seasonal influenza monobulks, to characterize the concentrated antigens [...]

Encapsulation and in vitro characterization of protein in PLGA-chitosan nanoparticles for efficient protein delivery

Subbarayan P., Dennis V.A., Lee C., Nyairo E., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections affecting mainly elderly, infants and the immunocompromised worldwide. As yet, a safe and effective vaccine has not been developed [...]

A Non-toxic Cellular Staining Agent Based on Fluorescently Labeled Poly[2-(methacryloyloxy)ethyl phosphorylcholine]

Warren N.J., Massignani M., Armes S.P., Battaglia G., Lewis A.L., The University of Sheffield, UK

The biocompatible monomer 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) is polymerized by atom transfer radical polymerization (ATRP) using a fluorescent ATRP initiator and fluorescent comonomers. In this study we show that PMPC alone can be used as a [...]

Synthesis, Characterization and Antibacterial Activity of Glycol Chitosan Modified Superparamagnetic Nanoparticles

Chen B.H., Inbaraj B.S., Fu Jen University, TW

Superparamagnetic iron oxide nanoparticles (IONPs) are particularly attractive as antibacterial agents owing to their precise bacterial biofilm and cell targeting in vivo achieved by magnetic driving. In this work, superparamagnetic IONPs modified with water-soluble glycol [...]

PEG Incorporated Polymeric Microcapsules for Intramyocardial Delivery of Stem Cells Genetically Modified by Baculovirus

Paul A., Khan A.A., Abbasi S., Shum-Tim D., Prakash S., McGill University, CA

The ability of mesenchymal stem cells to self-renew and differentiate into specialized cell lineages makes them promising tools for regenerative medicine. Local injection and use of scaffolds had been employed earlier to deliver these cells; [...]

UltraDOTs : Multifunctional Ion-Selective Delivery Capsules

Walters J.D., Hall E.A.H., University of Cambridge, UK

Emerging from the sensing capabilities of the particle sensors, we have developed a platform technology to produce a family of monodisperse capsule structures ranging from the nano to the micro in their diameters and shell [...]