Papers – Page 37 – TechConnect Briefs

Carbon Nanotube Array Sensor for MEMS Lab-on-a-chip

Joseph L.B., Veedu V., Garmire D., Oceanit and University of Hawaii, US

Lab-on-a-chip devices have the potential to provide point-of-care diagnostics that can save many thousands of lives per year. One of the primary limitations to wide-spread adoption of lab-on-a-chips is the excessive cost of fabrication and [...]

Development of a Flow-cell System to Quantify Analyte-receptor Binding Kinetics Utilizing Guided-mode Resonance Sensors

Wawro D., Zimmerman S., Ding Y., Magnusson R., Moss E., Michalik J., Resonant Sensors Incorporated, US

A novel flow-cell system integrated with a guided-mode resonance sensor element array is presented. The association/disassociation binding cycle is monitored for protein-protein and protein-cell interactions. The real-time binding interactions of the antibody IgG and protein-A [...]

Force Discrimination for Enhanced Biosensor Specificity of Micro-Retroreflector Assays

Knoop J.D., Kemper S.M., Sherlock T., Cacao E., Ruchhoeft P., Willson R.C., University of Houston, US

In nearly all diagnostic/bioanalytical methods other than mass spectrometry, what is actually detected is a label of some sort, and the sensitivity and simplicity of detection of this label limits assay performance. Non-specific interactions between [...]

Precise positioning of particles in microwells within horizontal DEP cages

Lombardini M., Bocchi M., Giulianelli L., Guerrieri R., ARCES, IT

The analysis and manipulation of one or few biological cells or artificial particles in the micron size range is a fundamental requirement in various life sciences applications such as sorting of rare cells or high-efficient [...]

Identification of bacterial drug resistance in blood

Kaittanis C., Nath S., Perez J.M., University of Central Florida, US

Development of antibiotic resistance by microorganisms has been on the rise in recent years. Therefore, identifying drug resistant strains and effective antibiotic agents is critical. Traditional microbiological methods assess antimicrobial susceptibility within 24 to 48 [...]

Understanding the formation and adsorption of 2-dimensional and 3-dimensional protein aggregates on a solid surface

Rabe M., Verdes D., Seeger S., University of Zurich, CH

We have comprehensively investigated the structure of protein assemblies that form spontaneously upon protein adsorption on solid interfaces using a surface sensitive fluorescence imaging technique. It was found that proteins usually do not cover surfaces [...]

Ultrasensitive Protein Detection Using an Au/ZnO SPR-Based Biosensor

Chang C-C, Lin C-W, Lin S-H, Chiu N.-F., Lin C-W, Lin S-H, National Taiwan University, TW

In this study, we demonstrated that the Au/ZnO nanocomposite films could be effectively used to enhance the performance of SPR for the detection of tumor marker. Carbohydrate antigen 15.3 (CA15.3) tumor marker for breast cancer [...]

Multiple drugs of abuse test for saliva specimen on a single lab-on-a-film-chip using electrochemical immunoassay

Kim Y.H., Park J.H., Nam H.H., Choi M.H., Jung S.H., Song G.J., Nano-Ditech Corporation, US

A novel diagnostic electrochemical immunoassay device integrating lab-on-a-film-chip (LOFC) and microfluidic technologies with chromatographic methods of rapid immunoassays for In Vitro Diagnostics (IVD) has been developed. This LOFC device is produced by a lithography technique [...]

Futurodontics – An Introduction

Borthakur B.J., Mahatma Gandhi Post Graduate Institute of Dental Sciences (Govt. of Puducherry Institution), India., IN

Summery: “The best way to predict the future is to create it”. Anonymous Nanofillers used in dental composites give superior nanomechanical & optical properties & reduction in polymerization shrinkage. To understand the nature’s biology is [...]

Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

Resheto I.V., Deev S.M., Chuvilin D.Y., Panchenko V.Y., Sukharev S.S., Streltsova E.A., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]