TechConnect Proceedings Papers
Month: May 2007
Nanoplex(TM) Biotags: Near-IR Excited, Highly Multiplexed Nanoparticulate Optical Detection Tags for Diagnostic Assays
Oxonica Inc has developed a novel optical detection tag for use in point of care diagnostics, cellular imaging assays, and life science assays. Nanoplex(TM) Biotags are silica coated Au nanoparticles that, by virtue of surface [...]
Peptide Nucleic Acids Modified Nano-Biosensor for Early Cancer Diagnosis
Epigenetics is proving to have an increasingly important role in both human development and disease, particularly cancer. DNA methylation is one of two epigenetic alterations. A distinct set of tumor types has a high level [...]
Rapid Isothermal Amplification and Multiplexed Surface Detection of Short DNA Sequences
We have coupled a novel isothermal amplification method for short oligonucleotides (EXPAR) with solution and surface-based detection involving DNA-functionalized gold nanospheres. In these assays, a trigger oligonucleotide is exponentially amplified and converted to a reporter [...]
DNA Detection Using Metal-Fluorescence Interactions on Two-Dimensionally Assembled Gold Nanoparticles
We developed a novel DNA detection system using a single stranded probe oligonucleotide with a fluorophore immobilized on two-dimensionally assembled gold nanoparticles. This system enables the detection of amplified DNAs without fluorescence labeling. In the [...]
Development of a Magnetically Triggered Drug Delivery System using Thermoresponsive Grafted Polymer Networks with Magnetic Nanoparticles
A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event (Brazel et al., 2006) was developed. The desirable carrier [...]
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases
Leuschner C., Kumar C., Hansel W., Branca R.T., Galiana G., Warren W., Hormes F., Pennington Biomedical Research Center, US
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases LEUSCHNER C1, KUMAR C2, Hansel W 1,BRANCA RT3, GALIANA G3, WARREN WS3 , HORMES F2. 1Pennington Biomedical Research Center, Baton Rouge, LA, USA, 2Center [...]
Hyperhtermia effect of surface-modified magnetite nanoparticles in a microfluid system
Fe3O4 nanoparticles (NPs) was first synthesized via coprecipiatation. After synthesis and purification of the Fe3O4 NPs, poly(acrylic acid) (PAA) was coated on them at specified conditions. The coating process is not possible at pH higher [...]
New carrier for protein and drug delivery based on injectable Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) pH/temperature hydrogel
Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) - a novel pH/temperature sensitive and biodegradable hydrogel copolymer used for drug and protein delivery was synthesized. Bovine insulin (BI) and human growth hormone (HGH) loaded well to the copolymer [...]
In Vivo Protein Transduction: Penetration of the Biologically Active HIV-1 Tat Mediated Cu,Zn-Superoxide Dismutase Rescues Murine Skin from Oxidative Stress
Liu T-P, Chen C-T, Chen Y-P, Chou C-M, Chang Y-C, Chiu T-T, Chen C-T, Chen Y-P, Taipei Medical University, TW
Reactive oxygen species (ROS), derived from the metabolism of oxygen and exist inherently in all aerobic organisms, lead to oxidative damage in a cell, tissue, or organ. This damage can affect a specific molecule or [...]