Materials for Drug & Gene Delivery

Drug Delivery with Light-Activated Gold-Coated Liposomes

Orsinger G.V., Leung S.J., Knights S.S., Williams J.D., Romanowski M., University of Arizona, US

With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The described biocompatible composite delivery vehicle enables encapsulation and selective release of [...]

Triple protection delivery system for retinaldehyde: Preparation, skin penetration and controlled release at the hair follicles

Supmuang P., Wanichwecharungruang S., Chulalongkorn University, TH

Vitamin A and its derivatives including retinaldehyde possess serious instability problem. To continuously supply skin with un-degraded retinaldehyde, nanoparticles which could penetrate into skin via hair follicles and then slowly release this vitamin A derivative [...]

Electrically-Controlled Drug Release System to Assist Wound Healing

Zhu S., Mbugua J., Chase M., Maskrod J., Jung J.H., Nicholson III T., Fabrizio E., Mercado R., Crosslink, US

The localized, controlled delivery of therapeutic agents is an attractive prospect for drugs with detrimental systemic effects at large dosages. An electronically-controlled drug delivery system (DDS) for the controlled release of negatively charged model compounds [...]

Nanoencapsulated Drug-Carrying System for Photodynamic Antimicrobial Chemotherapy (PACT)

Kalapala G.K.M., Fu P.K.-L., Governors State University, US

Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States,the expense of treating [...]

Concentration and characterization of influenza antigen bulks for potential novel vaccine delivery applications

Scampini A., Gallorini S., Baudner B.C., Palladino G., Singh M., O’Hagan D.T., Kommareddy S., Novartis, US

As a part of reformulating influenza vaccines by novel delivery technologies it is essential to work with concentrated antigens. The purpose of this study was to concentrate seasonal influenza monobulks, to characterize the concentrated antigens [...]

Encapsulation and in vitro characterization of protein in PLGA-chitosan nanoparticles for efficient protein delivery

Subbarayan P., Dennis V.A., Lee C., Nyairo E., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections affecting mainly elderly, infants and the immunocompromised worldwide. As yet, a safe and effective vaccine has not been developed [...]

A Non-toxic Cellular Staining Agent Based on Fluorescently Labeled Poly[2-(methacryloyloxy)ethyl phosphorylcholine]

Warren N.J., Massignani M., Armes S.P., Battaglia G., Lewis A.L., The University of Sheffield, UK

The biocompatible monomer 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) is polymerized by atom transfer radical polymerization (ATRP) using a fluorescent ATRP initiator and fluorescent comonomers. In this study we show that PMPC alone can be used as a [...]

Synthesis, Characterization and Antibacterial Activity of Glycol Chitosan Modified Superparamagnetic Nanoparticles

Chen B.H., Inbaraj B.S., Fu Jen University, TW

Superparamagnetic iron oxide nanoparticles (IONPs) are particularly attractive as antibacterial agents owing to their precise bacterial biofilm and cell targeting in vivo achieved by magnetic driving. In this work, superparamagnetic IONPs modified with water-soluble glycol [...]

PEG Incorporated Polymeric Microcapsules for Intramyocardial Delivery of Stem Cells Genetically Modified by Baculovirus

Paul A., Khan A.A., Abbasi S., Shum-Tim D., Prakash S., McGill University, CA

The ability of mesenchymal stem cells to self-renew and differentiate into specialized cell lineages makes them promising tools for regenerative medicine. Local injection and use of scaffolds had been employed earlier to deliver these cells; [...]