Diagnostics & Bioimaging – Page 4

Discriminated properties of PEI functionalized gold nanoparticles (Au-PEIs) predetermined by synthetic routes of ligand exchange and reduction processes: Paths and Fates

Cho T.J., Gorham J.M., Pettibone J.M., Hackley V.A., National Institute of Standards and Technology, US

Polyethyleneimine (PEI) functionalized AuNPs (Au-PEIs) have potential use as positively charged gold nanoparticles (AuNPs) for nano-medicinal applications, due to their cationic surfaces that promote cellular uptake and gene transfection.1-6 Au-PEIs can be prepared by one [...]

Accelerated Neutral Atom Beam processing of medical devices enhances tissue integration while reducing bacterial attachment

Khoury J., Phok B., Kirkpatrick S., Walsh M., Shashkov D., Exogenesis Corp, US

Accelerated Neutral Atom Beam (ANAB) technology is a low energy accelerated particle beam gaining acceptance as a tool for nano-scale surface modification of implantable medical devices. ANAB is created by acceleration of 2. METHODS neutral [...]

Remote control of mechano-sensory function of primary cilia by Fe2O3 nanoparticles in ciliopathic animal models

Pala R., Nauli S.M., Chapman University and University of California Irvine, US

In the present studies, we designed a cilia-targeted delivery system to deliver fenoldopam (FD) specifically to the primary cilia. Hence, we devised the iron oxide nanoparticle (Fe2O3-NP)-based technology for ciliotherapy. Dynamic light scattering measurements showed [...]

Bacteria Inhibitory Action of Peptides P753 and P359 in 2D and 3D Cell Cultures

Masuda J., Vig K., University of Hawaii at Manoa, US

The current study investigated two proprietary peptides, p359 and p753, for their antibacterial activity against Escherichia coli (E.Coli) and Staphylococcus aureus (S. aureus). Minimum Inhibitory Concentration (MIC) of bacteria for p359 and p753 was 50μg/mL [...]

Biotech & Medical

Customized Nanoparticle Probes for Biomedical Imaging, Diagnostics and Therapeutics Applications

Nallathamby P., University of Notre Dame, US

The modular synthetic approach that was developed to design a spectral library of core-shell nanoparticle contrast agents, which will have broad applications in biomedical imaging due to the potential for multi-modal imaging (e.g., fluorescence, MRI, [...]

RECAL: A New Ultrastable Luminescent Probe for Bioimaging

Borders B.C., Kang C.H., Brozik J.A., Photon Biosciences, LLC, US

Luminescent probes, such as fluorescent proteins, fluorescent dyes, phosphorescent dyes, and quantum dots, are important tools in biology, biophysics, and medical diagnostics. While these tools are incredibly useful and are suitable for use in many [...]

Functionalized Carbon Nanotube-based Microelectronic Sensor Array for Early Diagnosis of Alzheimer’s Disease

Johnston A.S., Tang Y., Alam M.M., InnoSense LLC, US

We designed and developed a lab-on-a-chip for the early diagnosis of Alzheimer’s Disease (AD) based on our patent-pending innovative nanotechnology by utilizing patterned microelectronic sensor devices for detecting Food and Drug Administration (FDA)-approved AD biomarkers [...]

Quantitative Electrolateral Flow Immunosensor (ELLI): Dengue Triage and Stroke Prognosis Case Studies

Sinawang P.D., Fajs L., Marks R.S., Ben-Gurion University of the Negev, IL

The development of a rapid, affordable, and sensitive diagnostic kit for point-of-care is important in most healthcare settings; however, only a few exhibit the needed quantitative capability. Our technology, ELLI, is a patented diagnostic device [...]

Nanobiomimetic Superlattice Superconductive/Memristive Organometallic Devices at Room Temperature Serve as Chronoamperometric Sensors for sub fg/mL Collagen-1 Detection in Human Serum

Chen E.T., Thornton J.T., Kissinger P.T., Duh S-H, Advanced Biomimetic Sensors, Inc., US

Superconductive/Memristive devices have potential applications in supercomputing and in health industry was proposed in literature. Clinically detection range at low concentration for collagen-1 is difficult to accomplish due to the denaturing of protein Matrix Matelloprotinase-2 [...]