Biomaterials – Page 123 – TechConnect Briefs

Structure-Function Relations in Self-Assembled Sphingolipids at Gas-Water Interfaces

Vaknin D., Ames Lab, and Iowa State University, US

The development in understanding cell membrane structure and function has been historically intertwined with that of the monomolecular Langmuir layer of amphiphiles at air-aqueous interfaces. Here, we present synchrotron structural studies of a variety of [...]

A Glucose Biosensor using Au Nanoparticle Modified Glucose Oxidase

Meng X., Ren X., Tang F., Chinese Academy of Sciences, CN

Biosensors have a wide field of potential applications in biotechnology, process control and medicine, mainly for accurate measurement of the analyte concentration of physiological fluid to diagnose some diseases. The development of enzyme-based biosensor technology [...]

MembraneChipTM : Arrays of Natively Displayed Membrane Targets for Novel Drug Discovery

Yamazaki V., Nguyen L.T., Schafer R.J., Ulman N., Groves J.T., Proteomic Systems, Inc., US

For the first time, naturally fluid and functional biological membranes have been integrated into a scaleable system. Previously-inaccessible membrane targets can be presented in their native environment. Domains of membrane targets naturally displayed in cell [...]

Mimicking Immune Processes by Positioning Antibodies on Surfaces — A Nanoengineering Approach

Liu G-y., Liu M., Amro N., Komanicky V., Liu G-y., Liu M., University of California Davis, US

Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well-known in solution phase, controlling the valency on surfaces has not been attempted. Using scanning probe [...]

Biomimetic Membranes

System Identification for Motion of Proteins Using an AFM-based Nanorobotic Manipulation

Park J., Kim B-K., Kim D-H., Kim B-K., Kim D-H., Lee K-I., Korea Institute of Science and Technology, KR

It is greatly important to understand the mechanics of AFM-based nanorobotic manipulation for efficient and reliable handling of nanoparticles. Robust motion control of an AFM-based nanorobotic manipulation is much challenging due to uncertain mechanics in [...]

Converging Technologies (NBIC)

Bainbridge W.S., National Science Foundation, US

The convergence of nanotechnology, biotechnology, information technology and cognitive science can greatly improve human performance over the next ten to twenty years. The chief areas of application include: expanding human cognition and communication, improving human [...]

A Fokker-Planck Approach For Modeling Integrated NanoBio Systems

Jenkins J.W., Sundaram S., CFD Research Corporation, US

Physics-based, high-fidelity simulations have emerged as indispensable tools in the design of complex, microfluidic devices (lab-on-chip). However, ab-initio analysis becomes increasingly complicated as the dimensions of the device approach nanoscales and molecular information/interactions must be [...]

Biologically Inspired Controls over Assembly of Crystalline Nanostructures

De Yoreo J.J., Orme C.A., Qiu R., Dove P.M., Lawrence Livermore National Laboratory, US

By utilizing small molecules and proteins to modulate crystal nucleation and growth, living organisms produce single nanocrystals and nanocrystal composites that exhibit control over the location, phase and crystallographic orientation of the nuclei, as well [...]

DNA base damage: A Car-Parrinello Molecular Dynamics Study of Guanine and Thymine with an OH Radical

Wu Y., Mundy C.J., Colvin M.E., Car R., Lawrence Livermore National Labs, US

Understanding the basic chemistry of radicals and DNA bases is an important step in characterizing the potential damage to DNA. The chemical level understanding of such damage has far reaching implications for radiation therapy, health [...]